TY - JOUR
T1 - The clinical implementation of primary HPV screening
AU - Mariani, Luciano
AU - Igidbashian, Sarah
AU - Sandri, Maria Teresa
AU - Vici, Patrizia
AU - Landoni, Fabio
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Objective: To evaluate, from a gynecology perspective, the transition from cytology-based HPV screening to primary HPV screening. Methods: Studies examining switching from cytology-based screening to primary HPV-DNA testing with triaging of patients with positive test results were retrieved and reviewed, with a particular focus on screening in an Italian setting. Results: The increased complexity of patient-management decisions when implementing HPV-based screening was a critical issue discussed in the literature. The change in strategy represents a paradigm shift in moving from a medical perspective of identifying the disease in individual patients, to a public-healthcare perspective of excluding HPV from the healthy population and identifying a small sub-group of individuals at increased risk of HPV. Conclusion: With knowledge about HPV screening evolving rapidly, new programs and related algorithms need to be sufficiently flexible to be adjusted according to ongoing research and the validation of new assays. The establishment of a national working group (including epidemiologists, gynecologists, pathologists, and healthcare providers) will be necessary to properly implement and govern this important technical and cultural transition.
AB - Objective: To evaluate, from a gynecology perspective, the transition from cytology-based HPV screening to primary HPV screening. Methods: Studies examining switching from cytology-based screening to primary HPV-DNA testing with triaging of patients with positive test results were retrieved and reviewed, with a particular focus on screening in an Italian setting. Results: The increased complexity of patient-management decisions when implementing HPV-based screening was a critical issue discussed in the literature. The change in strategy represents a paradigm shift in moving from a medical perspective of identifying the disease in individual patients, to a public-healthcare perspective of excluding HPV from the healthy population and identifying a small sub-group of individuals at increased risk of HPV. Conclusion: With knowledge about HPV screening evolving rapidly, new programs and related algorithms need to be sufficiently flexible to be adjusted according to ongoing research and the validation of new assays. The establishment of a national working group (including epidemiologists, gynecologists, pathologists, and healthcare providers) will be necessary to properly implement and govern this important technical and cultural transition.
KW - Cervical cancer screening
KW - HPV test
KW - Primary HPV screening
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U2 - 10.1002/ijgo.12065
DO - 10.1002/ijgo.12065
M3 - Review article
C2 - 28099686
AN - SCOPUS:85020374734
VL - 136
SP - 266
EP - 271
JO - International Journal of Gynecology and Obstetrics
JF - International Journal of Gynecology and Obstetrics
SN - 0020-7292
IS - 3
ER -