The clinical overlap between the corticobasal degeneration syndrome and other diseases of the frontotemporal spectrum: Three case reports

Alberto Raggi, Alessandra Marcone, Sandro Iannaccone, Valeria Ginex, Daniela Perani, Stefano F. Cappa

Research output: Contribution to journalArticle

Abstract

The corticobasal degeneration syndrome has been suggested to be part of a complex of conditions (including the different subtypes of frontotemporal dementia and progressive supranuclear palsy), which reflect a spectrum of pathological substrates. This concept is supported by the frequent clinical overlap that can be observed among patients diagnosed with these conditions. We report three clinical cases, characterized by the overlap of the clinical features of corticobasal degeneration syndrome with, respectively, nonfluent progressive aphasia, progressive supranuclear palsy and semantic dementia. Current diagnostic criteria emphasize differences in clinical presentation, which probably reflect the preferential location of pathology in the early stages of disease. However, with disease progression, a considerable clinical overlap can be expected among the different syndromes. This concept should be extended not only to the cognitive and behavioural features of the frontotemporal dementia subtypes, but also to the movement disorders of corticobasal degeneration and supranuclear palsy.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalBehavioural Neurology
Volume18
Issue number3
Publication statusPublished - 2007

Keywords

  • Corticobasal degeneration
  • Frontotemporal dementia
  • Nonfluent progressive aphasia
  • Progressive supranuclear palsy
  • Semantic dementia

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

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