Diabetic foot is a severe complication of diabetes mellitus that may affect up to 25% of patients in the course of their lifetime, with far-reaching effects on their quality of life, incidence of hospitalization, loss of independence, and even survival. It results from the interaction of the chronic micro- and macroangiopathic complications of diabetes, with a substantial role of neuropathy. This article reviews the pathophysiological mechanisms triggering these complications, how they interact and eventually lead to diabetic foot, and the therapeutic prospects - starting from prevention.
|Number of pages||10|
|Journal||Giornale Italiano di Diabetologia e Metabolismo|
|Publication status||Published - 2014|
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism