BACKGROUND: The clinical presentation of primary hyperparathyroidism (PHPT) has changed widely in developed countries in the last few decades. We evaluated its variations in our series over a 20-year period, i.e. 1997-2016.
PATIENTS: A retrospective survey was conducted in our series of 364 well-characterized consecutive patients, arbitrarily divided into four consecutive 5-year periods at diagnosis.
RESULTS: In the overall series, only eGFR and urinary calcium showed a significant upward trend (p=0.032 and 0.039, respectively), whereas demographic and clinical characteristics were stable. The urinary calcium upward trend was confirmed also for the subgroup of symptomatic patients (p=0.013). No difference was observed in the demographic, clinical and biochemical characteristics of asymptomatic patients, or in the fraction of patients meeting surgical criteria.
CONCLUSIONS: Clinical presentation of PHPT was stable over 20 years in our large series.
ABBREVIATIONS: 25OHD = 25-hydroxy-vitamin D; DXA = dual X-ray absorptiometry; eGFR = estimated glomerular filtration rate; F = female; M = male; NHS = National Health System; PHPT = primary hyperparathyroidism; PTH = parathyroid hormone; UCa = urinary calcium; US = ultrasound.