The clinical significance of melatonin serum determination in oncological patients and its correlations with GH and PRL blood levels

P. Lissoni, A. Bastone, R. Sala, R. Mauri, F. Rovelli, S. Viviani, E. Bajetta, D. Esposti, G. Esposti, L. Di Bella, F. Fraschini

Research output: Contribution to journalArticlepeer-review

Abstract

In order to investigate the pineal function and its relation with the hypophysis in human neoplasms, melatonin and GH serum levels were determined in 63 patients, 42 affected by solid tumours and 21 by lymphoma or leukaemia. In women with breast cancer PRL was also measured. Melatonin, GH and PRL were evaluated in 52 healthy subjects acting as controls. The oncological patients showed significantly higher mean melatonin serum levels than the control subjects. Mean melatonin values were lower in patients with solid tumours who had metastases, than in cases without metastases. Chemotherapy caused an evident decrease in melatonin levels. Surgery was followed by a fall in melatonin in patients without metastases. Mean GH serum levels observed in oncological patients were similar to those in control subjects and were not influenced by therapy. PRL levels were within the normal range in women suffering from breast cancer.

Original languageEnglish
Pages (from-to)949-957
Number of pages9
JournalEuropean Journal of Cancer and Clinical Oncology
Volume23
Issue number7
DOIs
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Oncology

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