The clinical value of myocardial blood flow measurement

Paolo G. Camici, Ornella E. Rimoldi

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

PET provides robust and reproducible measurements of regional myocardial blood flow in milliliters per minute per gram of tissue, providing unique pathophysiologic and diagnostic information on the function of the coronary macro- and microcirculation. There is compelling evidence to suggest that in many instances abnormalities of global myocardial perfusion are demonstrated in individuals with either coronary risk factors for coronary artery disease or different myocardial diseases in the absence of angiographically demonstrable stenosis of the epicardial coronary arteries. In this context, measurement of myocardial blood flow gives unique diagnostic information regarding the function of the coronary microcirculation and provides a quantitative surrogate endpoint against which the efficacy of treatments can be established.

Original languageEnglish
Pages (from-to)1076-1087
Number of pages12
JournalJournal of Nuclear Medicine
Volume50
Issue number7
DOIs
Publication statusPublished - Jul 1 2009

Fingerprint

Microcirculation
Coronary Stenosis
Regional Blood Flow
Cardiomyopathies
Coronary Artery Disease
Perfusion
Biomarkers

Keywords

  • Cardiovascular disease
  • Myocardial blood flow
  • Noninvasive measurement

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

The clinical value of myocardial blood flow measurement. / Camici, Paolo G.; Rimoldi, Ornella E.

In: Journal of Nuclear Medicine, Vol. 50, No. 7, 01.07.2009, p. 1076-1087.

Research output: Contribution to journalArticle

Camici, Paolo G. ; Rimoldi, Ornella E. / The clinical value of myocardial blood flow measurement. In: Journal of Nuclear Medicine. 2009 ; Vol. 50, No. 7. pp. 1076-1087.
@article{0bab445c884e45d8a7f20c10177c2fda,
title = "The clinical value of myocardial blood flow measurement",
abstract = "PET provides robust and reproducible measurements of regional myocardial blood flow in milliliters per minute per gram of tissue, providing unique pathophysiologic and diagnostic information on the function of the coronary macro- and microcirculation. There is compelling evidence to suggest that in many instances abnormalities of global myocardial perfusion are demonstrated in individuals with either coronary risk factors for coronary artery disease or different myocardial diseases in the absence of angiographically demonstrable stenosis of the epicardial coronary arteries. In this context, measurement of myocardial blood flow gives unique diagnostic information regarding the function of the coronary microcirculation and provides a quantitative surrogate endpoint against which the efficacy of treatments can be established.",
keywords = "Cardiovascular disease, Myocardial blood flow, Noninvasive measurement",
author = "Camici, {Paolo G.} and Rimoldi, {Ornella E.}",
year = "2009",
month = "7",
day = "1",
doi = "10.2967/jnumed.108.054478",
language = "English",
volume = "50",
pages = "1076--1087",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "7",

}

TY - JOUR

T1 - The clinical value of myocardial blood flow measurement

AU - Camici, Paolo G.

AU - Rimoldi, Ornella E.

PY - 2009/7/1

Y1 - 2009/7/1

N2 - PET provides robust and reproducible measurements of regional myocardial blood flow in milliliters per minute per gram of tissue, providing unique pathophysiologic and diagnostic information on the function of the coronary macro- and microcirculation. There is compelling evidence to suggest that in many instances abnormalities of global myocardial perfusion are demonstrated in individuals with either coronary risk factors for coronary artery disease or different myocardial diseases in the absence of angiographically demonstrable stenosis of the epicardial coronary arteries. In this context, measurement of myocardial blood flow gives unique diagnostic information regarding the function of the coronary microcirculation and provides a quantitative surrogate endpoint against which the efficacy of treatments can be established.

AB - PET provides robust and reproducible measurements of regional myocardial blood flow in milliliters per minute per gram of tissue, providing unique pathophysiologic and diagnostic information on the function of the coronary macro- and microcirculation. There is compelling evidence to suggest that in many instances abnormalities of global myocardial perfusion are demonstrated in individuals with either coronary risk factors for coronary artery disease or different myocardial diseases in the absence of angiographically demonstrable stenosis of the epicardial coronary arteries. In this context, measurement of myocardial blood flow gives unique diagnostic information regarding the function of the coronary microcirculation and provides a quantitative surrogate endpoint against which the efficacy of treatments can be established.

KW - Cardiovascular disease

KW - Myocardial blood flow

KW - Noninvasive measurement

UR - http://www.scopus.com/inward/record.url?scp=67650079957&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67650079957&partnerID=8YFLogxK

U2 - 10.2967/jnumed.108.054478

DO - 10.2967/jnumed.108.054478

M3 - Article

C2 - 19525470

AN - SCOPUS:67650079957

VL - 50

SP - 1076

EP - 1087

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

SN - 0161-5505

IS - 7

ER -