The coexistence of chronic lymphocytic leukemia and myeloproliperative neoplasms: A retrospective multicentric GIMEMA experience

Luca Laurenti, Michela Tarnani, Ilaria Nichele, Stefania Ciolli, Agostino Cortelezzi, Francesco Forconi, Davide Rossi, Francesca Romana Mauro, Giovanni D'Arena, Giovanni Del Poeta, Marco Montanaro, Fortunato Morabito, Caterina Musolino, Vincenzo Callea, Lorenzo Falchi, Alessandra Tedeschi, Achille Ambrosetti, Gianluca Gaidano, Giuseppe Leone, Robin Foà

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Abstract

Although the coexistence of chronic lymphocytic leukemia (CLL) and myeloproliferative neoplasms (MPN) has been sporadically reported in the literature, no systematic studies on this disease association are available. We retrospectively analyzed 46 patients affected by CLL/MPN referred by 15 Italian GIMEMA centers. The aim of this retrospective multicenter study was to define the following: clinico-biological characteristics, possible familiarity, clinical course of both diseases, and influence of MPN chemotherapy on the course of CLL. Among 46 patients, 30 patients were males, 16 patients were females; median age was 71 years. Only one case had familiar CLL. Myeloproliferative disorders consisted of essential thrombocytemia in 18 cases, polycythemia vera in 10 cases, chronic myeloid leukemia in 9 cases, primary myelofibrosis in 6 cases, and MPN/myelodysplastic syndrome in 3 cases. The lymphoproliferative disorder was diagnosed as monoclonal B-cell lymphocytosis in 8 patients and as Binet Stage A CLL in 38 patients. After a median follow-up of 49 months, 9 patients experienced progressive CLL and only 6 patients required treatment after a median of 57.5 months. The biological profile confirmed a subset of low-risk CLL. Twenty patients received chemotherapy for MPN without influence on the course of CLL: lymphocyte counts remained unchanged after 3, 6, and 12 months of treatment. This series is the largest so far reported in literature. The diagnosis of concomitant CLL/MPN is a rare event and lymphoproliferative disorders present a clinical indolent course with a low-risk biological profile. MPN therapy does not interfere with the prognosis of patients with CLL.

Original languageEnglish
Pages (from-to)1007-1012
Number of pages6
JournalAmerican Journal of Hematology
Volume86
Issue number12
DOIs
Publication statusPublished - Dec 2011

ASJC Scopus subject areas

  • Hematology

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    Laurenti, L., Tarnani, M., Nichele, I., Ciolli, S., Cortelezzi, A., Forconi, F., Rossi, D., Mauro, F. R., D'Arena, G., Del Poeta, G., Montanaro, M., Morabito, F., Musolino, C., Callea, V., Falchi, L., Tedeschi, A., Ambrosetti, A., Gaidano, G., Leone, G., & Foà, R. (2011). The coexistence of chronic lymphocytic leukemia and myeloproliperative neoplasms: A retrospective multicentric GIMEMA experience. American Journal of Hematology, 86(12), 1007-1012. https://doi.org/10.1002/ajh.22171