The coexistence of heart failure predicts short term mortality, but not disability, in patients with acute ischemic stroke treated with thrombolysis: The Florence area Registry

Vanessa Palumbo, Samuele Baldasseroni, Patrizia Nencini, Giovanni Pracucci, Francesco Arba, Benedetta Piccardi, Giosafat Andrea Marella, Mauro Di Bari, Gian Franco Gensini, Niccolò Marchionni, Domenico Inzitari

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Thrombolysis in ischemic stroke reduces disability but not mortality. Our aim was to evaluate the predictivity of heart failure (HF) diagnosis on 90-day mortality and disability in stroke patients undergoing thrombolysis. Material and methods: Hospital records of all consecutive stroke patients treated with thrombolysis at our University Hospital were reviewed. Clinical assessment for HF and echocardiogram were available for all patients according to the thrombolysis institutional protocol. History of HF, LVEF <40%, or BOSTON score ≥ 5 were tested as predictors. Results: Of 130 patients (age 66 ± 14 years, 64.6% males, baseline NIHSS 15.6 ± 8.8), 17 (13.1%) had a history of HF, 16 (12.7%) a BOSTON score ≥ 5, 13 (10.9%) a LVEF <40% and 24 (19.0%) met clinical criteria for HF diagnosis. Ninety-day mortality and incidence of disability were 16.1% and 36.1%, respectively. After adjustment for age, sex, baseline stroke severity and pre-stroke disability, LVEF <40% and clinical diagnosis of HF were predictors of 90-day mortality, (p = 0.007 and p = 0.037, respectively). Conclusion: Clinical diagnosis of HF predicts mortality, but not disability, in acute stroke patients undergoing thrombolysis. Unlike anamnestic record of HF, clinical evaluation of cardiac function, with estimation of LVEF, predicts mortality.

Original languageEnglish
Pages (from-to)552-557
Number of pages6
JournalEuropean Journal of Internal Medicine
Volume23
Issue number6
DOIs
Publication statusPublished - Sep 2012

Fingerprint

Registries
Heart Failure
Stroke
Mortality
Hospital Records
Incidence

Keywords

  • Acute ischemic stroke
  • Heart failure
  • Prognosis
  • Thrombolysis

ASJC Scopus subject areas

  • Internal Medicine

Cite this

The coexistence of heart failure predicts short term mortality, but not disability, in patients with acute ischemic stroke treated with thrombolysis : The Florence area Registry. / Palumbo, Vanessa; Baldasseroni, Samuele; Nencini, Patrizia; Pracucci, Giovanni; Arba, Francesco; Piccardi, Benedetta; Marella, Giosafat Andrea; Di Bari, Mauro; Gensini, Gian Franco; Marchionni, Niccolò; Inzitari, Domenico.

In: European Journal of Internal Medicine, Vol. 23, No. 6, 09.2012, p. 552-557.

Research output: Contribution to journalArticle

Palumbo, V, Baldasseroni, S, Nencini, P, Pracucci, G, Arba, F, Piccardi, B, Marella, GA, Di Bari, M, Gensini, GF, Marchionni, N & Inzitari, D 2012, 'The coexistence of heart failure predicts short term mortality, but not disability, in patients with acute ischemic stroke treated with thrombolysis: The Florence area Registry', European Journal of Internal Medicine, vol. 23, no. 6, pp. 552-557. https://doi.org/10.1016/j.ejim.2012.03.015
Palumbo, Vanessa ; Baldasseroni, Samuele ; Nencini, Patrizia ; Pracucci, Giovanni ; Arba, Francesco ; Piccardi, Benedetta ; Marella, Giosafat Andrea ; Di Bari, Mauro ; Gensini, Gian Franco ; Marchionni, Niccolò ; Inzitari, Domenico. / The coexistence of heart failure predicts short term mortality, but not disability, in patients with acute ischemic stroke treated with thrombolysis : The Florence area Registry. In: European Journal of Internal Medicine. 2012 ; Vol. 23, No. 6. pp. 552-557.
@article{1cdcbe39b6f7407da4791512af7a1469,
title = "The coexistence of heart failure predicts short term mortality, but not disability, in patients with acute ischemic stroke treated with thrombolysis: The Florence area Registry",
abstract = "Background: Thrombolysis in ischemic stroke reduces disability but not mortality. Our aim was to evaluate the predictivity of heart failure (HF) diagnosis on 90-day mortality and disability in stroke patients undergoing thrombolysis. Material and methods: Hospital records of all consecutive stroke patients treated with thrombolysis at our University Hospital were reviewed. Clinical assessment for HF and echocardiogram were available for all patients according to the thrombolysis institutional protocol. History of HF, LVEF <40{\%}, or BOSTON score ≥ 5 were tested as predictors. Results: Of 130 patients (age 66 ± 14 years, 64.6{\%} males, baseline NIHSS 15.6 ± 8.8), 17 (13.1{\%}) had a history of HF, 16 (12.7{\%}) a BOSTON score ≥ 5, 13 (10.9{\%}) a LVEF <40{\%} and 24 (19.0{\%}) met clinical criteria for HF diagnosis. Ninety-day mortality and incidence of disability were 16.1{\%} and 36.1{\%}, respectively. After adjustment for age, sex, baseline stroke severity and pre-stroke disability, LVEF <40{\%} and clinical diagnosis of HF were predictors of 90-day mortality, (p = 0.007 and p = 0.037, respectively). Conclusion: Clinical diagnosis of HF predicts mortality, but not disability, in acute stroke patients undergoing thrombolysis. Unlike anamnestic record of HF, clinical evaluation of cardiac function, with estimation of LVEF, predicts mortality.",
keywords = "Acute ischemic stroke, Heart failure, Prognosis, Thrombolysis",
author = "Vanessa Palumbo and Samuele Baldasseroni and Patrizia Nencini and Giovanni Pracucci and Francesco Arba and Benedetta Piccardi and Marella, {Giosafat Andrea} and {Di Bari}, Mauro and Gensini, {Gian Franco} and Niccol{\`o} Marchionni and Domenico Inzitari",
year = "2012",
month = "9",
doi = "10.1016/j.ejim.2012.03.015",
language = "English",
volume = "23",
pages = "552--557",
journal = "European Journal of Internal Medicine",
issn = "0953-6205",
publisher = "Elsevier B.V.",
number = "6",

}

TY - JOUR

T1 - The coexistence of heart failure predicts short term mortality, but not disability, in patients with acute ischemic stroke treated with thrombolysis

T2 - The Florence area Registry

AU - Palumbo, Vanessa

AU - Baldasseroni, Samuele

AU - Nencini, Patrizia

AU - Pracucci, Giovanni

AU - Arba, Francesco

AU - Piccardi, Benedetta

AU - Marella, Giosafat Andrea

AU - Di Bari, Mauro

AU - Gensini, Gian Franco

AU - Marchionni, Niccolò

AU - Inzitari, Domenico

PY - 2012/9

Y1 - 2012/9

N2 - Background: Thrombolysis in ischemic stroke reduces disability but not mortality. Our aim was to evaluate the predictivity of heart failure (HF) diagnosis on 90-day mortality and disability in stroke patients undergoing thrombolysis. Material and methods: Hospital records of all consecutive stroke patients treated with thrombolysis at our University Hospital were reviewed. Clinical assessment for HF and echocardiogram were available for all patients according to the thrombolysis institutional protocol. History of HF, LVEF <40%, or BOSTON score ≥ 5 were tested as predictors. Results: Of 130 patients (age 66 ± 14 years, 64.6% males, baseline NIHSS 15.6 ± 8.8), 17 (13.1%) had a history of HF, 16 (12.7%) a BOSTON score ≥ 5, 13 (10.9%) a LVEF <40% and 24 (19.0%) met clinical criteria for HF diagnosis. Ninety-day mortality and incidence of disability were 16.1% and 36.1%, respectively. After adjustment for age, sex, baseline stroke severity and pre-stroke disability, LVEF <40% and clinical diagnosis of HF were predictors of 90-day mortality, (p = 0.007 and p = 0.037, respectively). Conclusion: Clinical diagnosis of HF predicts mortality, but not disability, in acute stroke patients undergoing thrombolysis. Unlike anamnestic record of HF, clinical evaluation of cardiac function, with estimation of LVEF, predicts mortality.

AB - Background: Thrombolysis in ischemic stroke reduces disability but not mortality. Our aim was to evaluate the predictivity of heart failure (HF) diagnosis on 90-day mortality and disability in stroke patients undergoing thrombolysis. Material and methods: Hospital records of all consecutive stroke patients treated with thrombolysis at our University Hospital were reviewed. Clinical assessment for HF and echocardiogram were available for all patients according to the thrombolysis institutional protocol. History of HF, LVEF <40%, or BOSTON score ≥ 5 were tested as predictors. Results: Of 130 patients (age 66 ± 14 years, 64.6% males, baseline NIHSS 15.6 ± 8.8), 17 (13.1%) had a history of HF, 16 (12.7%) a BOSTON score ≥ 5, 13 (10.9%) a LVEF <40% and 24 (19.0%) met clinical criteria for HF diagnosis. Ninety-day mortality and incidence of disability were 16.1% and 36.1%, respectively. After adjustment for age, sex, baseline stroke severity and pre-stroke disability, LVEF <40% and clinical diagnosis of HF were predictors of 90-day mortality, (p = 0.007 and p = 0.037, respectively). Conclusion: Clinical diagnosis of HF predicts mortality, but not disability, in acute stroke patients undergoing thrombolysis. Unlike anamnestic record of HF, clinical evaluation of cardiac function, with estimation of LVEF, predicts mortality.

KW - Acute ischemic stroke

KW - Heart failure

KW - Prognosis

KW - Thrombolysis

UR - http://www.scopus.com/inward/record.url?scp=84864623690&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864623690&partnerID=8YFLogxK

U2 - 10.1016/j.ejim.2012.03.015

DO - 10.1016/j.ejim.2012.03.015

M3 - Article

C2 - 22863434

AN - SCOPUS:84864623690

VL - 23

SP - 552

EP - 557

JO - European Journal of Internal Medicine

JF - European Journal of Internal Medicine

SN - 0953-6205

IS - 6

ER -