Associazione sindrome di Sjogren-tiroidite di Hashimoto. Considerazioni su un caso

Translated title of the contribution: The coexistence of Sjogren's syndrome and Hashimoto's thyroiditis. Case report

V. Silipo, G. Sacerdoti, M. Fazio

Research output: Contribution to journalArticle

Abstract

Sjogren's syndrome (SS) is a chronic inflammatory autoimmune disease, mainly affecting the exocrine glands (mostly the salivary and the lachrymal). Autoantibodies anti Ro-SSA and La-SSb antigens are commonly found among patients affected by primary SS. Primary SS affected approximately 0.03% of the population, mainly older women (mean age 50 years). The clinical presentation of SS can be quite variable; generally the disease is localized on the lachrymal and salivary glands giving rise to severe or moderate oral and ocular dryness. In 5% of patients, however, there may be an extension of lymphoproliferation to extraglandular sites such as the lung, kidney, lymphnodes, skin, gastrointestinal tract, and bone marrow. When extraglandular involvement occurs, the disease may simulate or suggest lymphoma. The coexistence of this syndrome with other autoimmune diseases, such as LES, biliary cirrhosis, gastric achlorhydria, thyroiditis (particularly Hashimoto's thyroiditis) is reported in the literature. A case report about the coexistence of primary SS and euthyroid Hashimoto's thyroiditis (HT) in a woman, is described by the authors. Patients with SS have been found to be likely affected by HT. The etiopathogenesis of the overlap syndromes, in autoimmune diseases, isn't completely known yet, though several cases have been reported in the literature. Genetic proneness, characterized by particular HLA groups, plays an important role on the capacity of producing autoantibodies. Among other mechanisms which work along with genetic proneness, the autoantibodies cross-reactivity and the structural similarities of autoantigens are of interest. In conclusion, a possible common immuno-genetic mechanism seems to take part in the development of the overlap syndromes.

Original languageItalian
Pages (from-to)387-391
Number of pages5
JournalGiornale Italiano di Dermatologia e Venereologia
Volume131
Issue number6
Publication statusPublished - 1996

Fingerprint

Hashimoto Disease
Sjogren's Syndrome
Autoantibodies
Autoimmune Diseases
Achlorhydria
Exocrine Glands
Xerostomia
Thyroiditis
Biliary Liver Cirrhosis
Autoantigens
Salivary Glands
Gastrointestinal Tract
Lymphoma
Stomach
Bone Marrow
Kidney
Antigens
Lung
Skin
Population

ASJC Scopus subject areas

  • Dermatology

Cite this

Associazione sindrome di Sjogren-tiroidite di Hashimoto. Considerazioni su un caso. / Silipo, V.; Sacerdoti, G.; Fazio, M.

In: Giornale Italiano di Dermatologia e Venereologia, Vol. 131, No. 6, 1996, p. 387-391.

Research output: Contribution to journalArticle

@article{5cfebedd5d1f4505b55e343b61c0f8f6,
title = "Associazione sindrome di Sjogren-tiroidite di Hashimoto. Considerazioni su un caso",
abstract = "Sjogren's syndrome (SS) is a chronic inflammatory autoimmune disease, mainly affecting the exocrine glands (mostly the salivary and the lachrymal). Autoantibodies anti Ro-SSA and La-SSb antigens are commonly found among patients affected by primary SS. Primary SS affected approximately 0.03{\%} of the population, mainly older women (mean age 50 years). The clinical presentation of SS can be quite variable; generally the disease is localized on the lachrymal and salivary glands giving rise to severe or moderate oral and ocular dryness. In 5{\%} of patients, however, there may be an extension of lymphoproliferation to extraglandular sites such as the lung, kidney, lymphnodes, skin, gastrointestinal tract, and bone marrow. When extraglandular involvement occurs, the disease may simulate or suggest lymphoma. The coexistence of this syndrome with other autoimmune diseases, such as LES, biliary cirrhosis, gastric achlorhydria, thyroiditis (particularly Hashimoto's thyroiditis) is reported in the literature. A case report about the coexistence of primary SS and euthyroid Hashimoto's thyroiditis (HT) in a woman, is described by the authors. Patients with SS have been found to be likely affected by HT. The etiopathogenesis of the overlap syndromes, in autoimmune diseases, isn't completely known yet, though several cases have been reported in the literature. Genetic proneness, characterized by particular HLA groups, plays an important role on the capacity of producing autoantibodies. Among other mechanisms which work along with genetic proneness, the autoantibodies cross-reactivity and the structural similarities of autoantigens are of interest. In conclusion, a possible common immuno-genetic mechanism seems to take part in the development of the overlap syndromes.",
keywords = "autoimmunity, Hashimoto's thyroiditis, Sjogren's syndrome",
author = "V. Silipo and G. Sacerdoti and M. Fazio",
year = "1996",
language = "Italian",
volume = "131",
pages = "387--391",
journal = "Minerva dermatologica",
issn = "0392-0488",
publisher = "Edizioni Minerva Medica S.p.A.",
number = "6",

}

TY - JOUR

T1 - Associazione sindrome di Sjogren-tiroidite di Hashimoto. Considerazioni su un caso

AU - Silipo, V.

AU - Sacerdoti, G.

AU - Fazio, M.

PY - 1996

Y1 - 1996

N2 - Sjogren's syndrome (SS) is a chronic inflammatory autoimmune disease, mainly affecting the exocrine glands (mostly the salivary and the lachrymal). Autoantibodies anti Ro-SSA and La-SSb antigens are commonly found among patients affected by primary SS. Primary SS affected approximately 0.03% of the population, mainly older women (mean age 50 years). The clinical presentation of SS can be quite variable; generally the disease is localized on the lachrymal and salivary glands giving rise to severe or moderate oral and ocular dryness. In 5% of patients, however, there may be an extension of lymphoproliferation to extraglandular sites such as the lung, kidney, lymphnodes, skin, gastrointestinal tract, and bone marrow. When extraglandular involvement occurs, the disease may simulate or suggest lymphoma. The coexistence of this syndrome with other autoimmune diseases, such as LES, biliary cirrhosis, gastric achlorhydria, thyroiditis (particularly Hashimoto's thyroiditis) is reported in the literature. A case report about the coexistence of primary SS and euthyroid Hashimoto's thyroiditis (HT) in a woman, is described by the authors. Patients with SS have been found to be likely affected by HT. The etiopathogenesis of the overlap syndromes, in autoimmune diseases, isn't completely known yet, though several cases have been reported in the literature. Genetic proneness, characterized by particular HLA groups, plays an important role on the capacity of producing autoantibodies. Among other mechanisms which work along with genetic proneness, the autoantibodies cross-reactivity and the structural similarities of autoantigens are of interest. In conclusion, a possible common immuno-genetic mechanism seems to take part in the development of the overlap syndromes.

AB - Sjogren's syndrome (SS) is a chronic inflammatory autoimmune disease, mainly affecting the exocrine glands (mostly the salivary and the lachrymal). Autoantibodies anti Ro-SSA and La-SSb antigens are commonly found among patients affected by primary SS. Primary SS affected approximately 0.03% of the population, mainly older women (mean age 50 years). The clinical presentation of SS can be quite variable; generally the disease is localized on the lachrymal and salivary glands giving rise to severe or moderate oral and ocular dryness. In 5% of patients, however, there may be an extension of lymphoproliferation to extraglandular sites such as the lung, kidney, lymphnodes, skin, gastrointestinal tract, and bone marrow. When extraglandular involvement occurs, the disease may simulate or suggest lymphoma. The coexistence of this syndrome with other autoimmune diseases, such as LES, biliary cirrhosis, gastric achlorhydria, thyroiditis (particularly Hashimoto's thyroiditis) is reported in the literature. A case report about the coexistence of primary SS and euthyroid Hashimoto's thyroiditis (HT) in a woman, is described by the authors. Patients with SS have been found to be likely affected by HT. The etiopathogenesis of the overlap syndromes, in autoimmune diseases, isn't completely known yet, though several cases have been reported in the literature. Genetic proneness, characterized by particular HLA groups, plays an important role on the capacity of producing autoantibodies. Among other mechanisms which work along with genetic proneness, the autoantibodies cross-reactivity and the structural similarities of autoantigens are of interest. In conclusion, a possible common immuno-genetic mechanism seems to take part in the development of the overlap syndromes.

KW - autoimmunity

KW - Hashimoto's thyroiditis

KW - Sjogren's syndrome

UR - http://www.scopus.com/inward/record.url?scp=0030461169&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030461169&partnerID=8YFLogxK

M3 - Articolo

AN - SCOPUS:0030461169

VL - 131

SP - 387

EP - 391

JO - Minerva dermatologica

JF - Minerva dermatologica

SN - 0392-0488

IS - 6

ER -