Sjogren's syndrome (SS) is a chronic inflammatory autoimmune disease, mainly affecting the exocrine glands (mostly the salivary and the lachrymal). Autoantibodies anti Ro-SSA and La-SSb antigens are commonly found among patients affected by primary SS. Primary SS affected approximately 0.03% of the population, mainly older women (mean age 50 years). The clinical presentation of SS can be quite variable; generally the disease is localized on the lachrymal and salivary glands giving rise to severe or moderate oral and ocular dryness. In 5% of patients, however, there may be an extension of lymphoproliferation to extraglandular sites such as the lung, kidney, lymphnodes, skin, gastrointestinal tract, and bone marrow. When extraglandular involvement occurs, the disease may simulate or suggest lymphoma. The coexistence of this syndrome with other autoimmune diseases, such as LES, biliary cirrhosis, gastric achlorhydria, thyroiditis (particularly Hashimoto's thyroiditis) is reported in the literature. A case report about the coexistence of primary SS and euthyroid Hashimoto's thyroiditis (HT) in a woman, is described by the authors. Patients with SS have been found to be likely affected by HT. The etiopathogenesis of the overlap syndromes, in autoimmune diseases, isn't completely known yet, though several cases have been reported in the literature. Genetic proneness, characterized by particular HLA groups, plays an important role on the capacity of producing autoantibodies. Among other mechanisms which work along with genetic proneness, the autoantibodies cross-reactivity and the structural similarities of autoantigens are of interest. In conclusion, a possible common immuno-genetic mechanism seems to take part in the development of the overlap syndromes.
|Translated title of the contribution||The coexistence of Sjogren's syndrome and Hashimoto's thyroiditis. Case report|
|Number of pages||5|
|Journal||Giornale Italiano di Dermatologia e Venereologia|
|Publication status||Published - 1996|
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