The cognitive side of M1

Barbara Tomasino, Michele Gremese

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The primary motor cortex (M1) is traditionally implicated in voluntary movement control. In order to test the hypothesis that there is a functional topography of M1 activation in studies where it has been implicated in higher cognitive tasks we performed activation-likelihood-estimation (ALE) meta-analyses of functional neuroimaging experiments reporting M1 activation in relation to six cognitive functional categories for which there was a sufficient number of studies to include, namely motor imagery, working memory, mental rotation, social/emotion/empathy, language, and auditory processing. The six categories activated different sub-sectors of M1, either bilaterally or lateralized to one hemisphere. Notably, the activations found in the M1 of the left or right hemisphere detected in our study were unlikely due to button presses. In fact, all contrasts were selected in order to eliminate M1 activation due to activity related to the finger button press. In addition, we identified the M1 sub-region of Area 4a commonly activated by 4/6 categories, namely motor imagery and working memory, emotion/empathy, and language. Overall, our findings lend support to the idea that there is a functional topography of M1 activation in studies where it has been found activated in higher cognitive tasks and that the left Area 4a can be involved in a number of cognitive processes, likely as a product of implicit mental simulation processing.

Original languageEnglish
Article number298
JournalFrontiers in Human Neuroscience
Volume10
Issue numberJUNE2016
DOIs
Publication statusPublished - Jun 17 2016

Fingerprint

Imagery (Psychotherapy)
Short-Term Memory
Emotions
Language
Functional Neuroimaging
Motor Cortex
Fingers
Meta-Analysis

Keywords

  • ALE meta-analysis
  • Cognitive processing
  • FMRI
  • M1
  • Primary motor cortex

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neurology
  • Biological Psychiatry
  • Behavioral Neuroscience
  • Neuropsychology and Physiological Psychology

Cite this

The cognitive side of M1. / Tomasino, Barbara; Gremese, Michele.

In: Frontiers in Human Neuroscience, Vol. 10, No. JUNE2016, 298, 17.06.2016.

Research output: Contribution to journalArticle

Tomasino, Barbara ; Gremese, Michele. / The cognitive side of M1. In: Frontiers in Human Neuroscience. 2016 ; Vol. 10, No. JUNE2016.
@article{c1368305a2d14331ae68e936fc4872bc,
title = "The cognitive side of M1",
abstract = "The primary motor cortex (M1) is traditionally implicated in voluntary movement control. In order to test the hypothesis that there is a functional topography of M1 activation in studies where it has been implicated in higher cognitive tasks we performed activation-likelihood-estimation (ALE) meta-analyses of functional neuroimaging experiments reporting M1 activation in relation to six cognitive functional categories for which there was a sufficient number of studies to include, namely motor imagery, working memory, mental rotation, social/emotion/empathy, language, and auditory processing. The six categories activated different sub-sectors of M1, either bilaterally or lateralized to one hemisphere. Notably, the activations found in the M1 of the left or right hemisphere detected in our study were unlikely due to button presses. In fact, all contrasts were selected in order to eliminate M1 activation due to activity related to the finger button press. In addition, we identified the M1 sub-region of Area 4a commonly activated by 4/6 categories, namely motor imagery and working memory, emotion/empathy, and language. Overall, our findings lend support to the idea that there is a functional topography of M1 activation in studies where it has been found activated in higher cognitive tasks and that the left Area 4a can be involved in a number of cognitive processes, likely as a product of implicit mental simulation processing.",
keywords = "ALE meta-analysis, Cognitive processing, FMRI, M1, Primary motor cortex",
author = "Barbara Tomasino and Michele Gremese",
year = "2016",
month = "6",
day = "17",
doi = "10.3389/fnhum.2016.00298",
language = "English",
volume = "10",
journal = "Frontiers in Human Neuroscience",
issn = "1662-5161",
publisher = "Frontiers Media S. A.",
number = "JUNE2016",

}

TY - JOUR

T1 - The cognitive side of M1

AU - Tomasino, Barbara

AU - Gremese, Michele

PY - 2016/6/17

Y1 - 2016/6/17

N2 - The primary motor cortex (M1) is traditionally implicated in voluntary movement control. In order to test the hypothesis that there is a functional topography of M1 activation in studies where it has been implicated in higher cognitive tasks we performed activation-likelihood-estimation (ALE) meta-analyses of functional neuroimaging experiments reporting M1 activation in relation to six cognitive functional categories for which there was a sufficient number of studies to include, namely motor imagery, working memory, mental rotation, social/emotion/empathy, language, and auditory processing. The six categories activated different sub-sectors of M1, either bilaterally or lateralized to one hemisphere. Notably, the activations found in the M1 of the left or right hemisphere detected in our study were unlikely due to button presses. In fact, all contrasts were selected in order to eliminate M1 activation due to activity related to the finger button press. In addition, we identified the M1 sub-region of Area 4a commonly activated by 4/6 categories, namely motor imagery and working memory, emotion/empathy, and language. Overall, our findings lend support to the idea that there is a functional topography of M1 activation in studies where it has been found activated in higher cognitive tasks and that the left Area 4a can be involved in a number of cognitive processes, likely as a product of implicit mental simulation processing.

AB - The primary motor cortex (M1) is traditionally implicated in voluntary movement control. In order to test the hypothesis that there is a functional topography of M1 activation in studies where it has been implicated in higher cognitive tasks we performed activation-likelihood-estimation (ALE) meta-analyses of functional neuroimaging experiments reporting M1 activation in relation to six cognitive functional categories for which there was a sufficient number of studies to include, namely motor imagery, working memory, mental rotation, social/emotion/empathy, language, and auditory processing. The six categories activated different sub-sectors of M1, either bilaterally or lateralized to one hemisphere. Notably, the activations found in the M1 of the left or right hemisphere detected in our study were unlikely due to button presses. In fact, all contrasts were selected in order to eliminate M1 activation due to activity related to the finger button press. In addition, we identified the M1 sub-region of Area 4a commonly activated by 4/6 categories, namely motor imagery and working memory, emotion/empathy, and language. Overall, our findings lend support to the idea that there is a functional topography of M1 activation in studies where it has been found activated in higher cognitive tasks and that the left Area 4a can be involved in a number of cognitive processes, likely as a product of implicit mental simulation processing.

KW - ALE meta-analysis

KW - Cognitive processing

KW - FMRI

KW - M1

KW - Primary motor cortex

UR - http://www.scopus.com/inward/record.url?scp=84975217600&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84975217600&partnerID=8YFLogxK

U2 - 10.3389/fnhum.2016.00298

DO - 10.3389/fnhum.2016.00298

M3 - Article

VL - 10

JO - Frontiers in Human Neuroscience

JF - Frontiers in Human Neuroscience

SN - 1662-5161

IS - JUNE2016

M1 - 298

ER -