The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis

Rupesh Agrawal, Dinesh Visva Gunasekeran, Aniruddha Agarwal, Ester Carreño, Kanika Aggarwal, Bhaskar Gupta, Dhananjay Raje, Somasheila I. Murthy, Mark Westcott, Soon Phaik Chee, Peter McCluskey, Ho Su Ling, Stephen Teoh, Luca Cimino, Jyotirmay Biswas, Shishir Narain, Manisha Agarwal, Padmamalini Mahendradas, Moncef Khairallah, Nicholas JonesIlknur Tugal-Tutkun, Kalpana Babu, Soumayava Basu, Richard Lee, Hassan Al-Dhibi, Bahram Bodaghi, Alessandro Invernizzi, Debra A. Goldstein, Carl P. Herbort, Talin Barisani-Asenbauer, Julio J. González-López, Sofia Androudi, Reema Bansal, Bruttendu Moharana, Sarakshi Mahajan, Simona Esposti, Anastasia Tasiopoulou, Sengal Nadarajah, Mamta Agarwal, Sharanya Abraham, Ruchi Vala, Joanne Lord, Ramandeep Singh, Aman Sharma, Kusum Sharma, Manfred Zierhut, Onn Min Kon, John Kempen, Emmett T. Cunningham, Andres Rousselot, Quan Dong Nguyen, Carlos Pavesio, Vishali Gupta

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: To contribute a global description of the spectrum of choroidal involvement in tubercular uveitis (TBU). Methods: Retrospective cohort study of TBU patients with choroidal involvement from 25 centers between January 2004 and December 2014. Medical records of patients with a minimum follow-up of 1 year were reviewed. Results: 245 patients were included. The phenotypic variations included serpiginous-like choroiditis (SLC) (46%), tuberculoma (13.5%), multifocal choroiditis (MFC) (9.4%), ampiginous choroiditis (9%), among others. 219 patients were treated with anti-tubercular therapy (ATT) (n = 219/245, 89.38%), 229 patients with steroids (n = 229/245, 93.47%) and 28 patients with immunosuppressive agents (n = 28/245, 11.42%). Treatment failure was noted in 38 patients (n = 38/245, 15.5%). Patients with SLC and ampiginous choroiditis appeared to have superior outcomes on survival analysis (p = 0.06). Conclusion: This study provides a comprehensive description of choroidal involvement in TBU. Patients with SLC and ampiginous choroiditis may have better clinical outcomes.

Original languageEnglish
JournalOcular Immunology and Inflammation
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Ocular Tuberculosis
Uveitis
Choroiditis
Tuberculoma
Immunosuppressive Agents
Survival Analysis
Treatment Failure
Medical Records
Cohort Studies
Retrospective Studies
Steroids

Keywords

  • Anti-tubercular therapy
  • choroiditis
  • ocular
  • tuberculosis
  • uveitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

Cite this

The Collaborative Ocular Tuberculosis Study (COTS)-1 : A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis. / Agrawal, Rupesh; Gunasekeran, Dinesh Visva; Agarwal, Aniruddha; Carreño, Ester; Aggarwal, Kanika; Gupta, Bhaskar; Raje, Dhananjay; Murthy, Somasheila I.; Westcott, Mark; Chee, Soon Phaik; McCluskey, Peter; Ling, Ho Su; Teoh, Stephen; Cimino, Luca; Biswas, Jyotirmay; Narain, Shishir; Agarwal, Manisha; Mahendradas, Padmamalini; Khairallah, Moncef; Jones, Nicholas; Tugal-Tutkun, Ilknur; Babu, Kalpana; Basu, Soumayava; Lee, Richard; Al-Dhibi, Hassan; Bodaghi, Bahram; Invernizzi, Alessandro; Goldstein, Debra A.; Herbort, Carl P.; Barisani-Asenbauer, Talin; González-López, Julio J.; Androudi, Sofia; Bansal, Reema; Moharana, Bruttendu; Mahajan, Sarakshi; Esposti, Simona; Tasiopoulou, Anastasia; Nadarajah, Sengal; Agarwal, Mamta; Abraham, Sharanya; Vala, Ruchi; Lord, Joanne; Singh, Ramandeep; Sharma, Aman; Sharma, Kusum; Zierhut, Manfred; Kon, Onn Min; Kempen, John; Cunningham, Emmett T.; Rousselot, Andres; Nguyen, Quan Dong; Pavesio, Carlos; Gupta, Vishali.

In: Ocular Immunology and Inflammation, 01.01.2018.

Research output: Contribution to journalArticle

Agrawal, R, Gunasekeran, DV, Agarwal, A, Carreño, E, Aggarwal, K, Gupta, B, Raje, D, Murthy, SI, Westcott, M, Chee, SP, McCluskey, P, Ling, HS, Teoh, S, Cimino, L, Biswas, J, Narain, S, Agarwal, M, Mahendradas, P, Khairallah, M, Jones, N, Tugal-Tutkun, I, Babu, K, Basu, S, Lee, R, Al-Dhibi, H, Bodaghi, B, Invernizzi, A, Goldstein, DA, Herbort, CP, Barisani-Asenbauer, T, González-López, JJ, Androudi, S, Bansal, R, Moharana, B, Mahajan, S, Esposti, S, Tasiopoulou, A, Nadarajah, S, Agarwal, M, Abraham, S, Vala, R, Lord, J, Singh, R, Sharma, A, Sharma, K, Zierhut, M, Kon, OM, Kempen, J, Cunningham, ET, Rousselot, A, Nguyen, QD, Pavesio, C & Gupta, V 2018, 'The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis', Ocular Immunology and Inflammation. https://doi.org/10.1080/09273948.2018.1489061
Agrawal, Rupesh ; Gunasekeran, Dinesh Visva ; Agarwal, Aniruddha ; Carreño, Ester ; Aggarwal, Kanika ; Gupta, Bhaskar ; Raje, Dhananjay ; Murthy, Somasheila I. ; Westcott, Mark ; Chee, Soon Phaik ; McCluskey, Peter ; Ling, Ho Su ; Teoh, Stephen ; Cimino, Luca ; Biswas, Jyotirmay ; Narain, Shishir ; Agarwal, Manisha ; Mahendradas, Padmamalini ; Khairallah, Moncef ; Jones, Nicholas ; Tugal-Tutkun, Ilknur ; Babu, Kalpana ; Basu, Soumayava ; Lee, Richard ; Al-Dhibi, Hassan ; Bodaghi, Bahram ; Invernizzi, Alessandro ; Goldstein, Debra A. ; Herbort, Carl P. ; Barisani-Asenbauer, Talin ; González-López, Julio J. ; Androudi, Sofia ; Bansal, Reema ; Moharana, Bruttendu ; Mahajan, Sarakshi ; Esposti, Simona ; Tasiopoulou, Anastasia ; Nadarajah, Sengal ; Agarwal, Mamta ; Abraham, Sharanya ; Vala, Ruchi ; Lord, Joanne ; Singh, Ramandeep ; Sharma, Aman ; Sharma, Kusum ; Zierhut, Manfred ; Kon, Onn Min ; Kempen, John ; Cunningham, Emmett T. ; Rousselot, Andres ; Nguyen, Quan Dong ; Pavesio, Carlos ; Gupta, Vishali. / The Collaborative Ocular Tuberculosis Study (COTS)-1 : A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis. In: Ocular Immunology and Inflammation. 2018.
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title = "The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis",
abstract = "Purpose: To contribute a global description of the spectrum of choroidal involvement in tubercular uveitis (TBU). Methods: Retrospective cohort study of TBU patients with choroidal involvement from 25 centers between January 2004 and December 2014. Medical records of patients with a minimum follow-up of 1 year were reviewed. Results: 245 patients were included. The phenotypic variations included serpiginous-like choroiditis (SLC) (46{\%}), tuberculoma (13.5{\%}), multifocal choroiditis (MFC) (9.4{\%}), ampiginous choroiditis (9{\%}), among others. 219 patients were treated with anti-tubercular therapy (ATT) (n = 219/245, 89.38{\%}), 229 patients with steroids (n = 229/245, 93.47{\%}) and 28 patients with immunosuppressive agents (n = 28/245, 11.42{\%}). Treatment failure was noted in 38 patients (n = 38/245, 15.5{\%}). Patients with SLC and ampiginous choroiditis appeared to have superior outcomes on survival analysis (p = 0.06). Conclusion: This study provides a comprehensive description of choroidal involvement in TBU. Patients with SLC and ampiginous choroiditis may have better clinical outcomes.",
keywords = "Anti-tubercular therapy, choroiditis, ocular, tuberculosis, uveitis",
author = "Rupesh Agrawal and Gunasekeran, {Dinesh Visva} and Aniruddha Agarwal and Ester Carre{\~n}o and Kanika Aggarwal and Bhaskar Gupta and Dhananjay Raje and Murthy, {Somasheila I.} and Mark Westcott and Chee, {Soon Phaik} and Peter McCluskey and Ling, {Ho Su} and Stephen Teoh and Luca Cimino and Jyotirmay Biswas and Shishir Narain and Manisha Agarwal and Padmamalini Mahendradas and Moncef Khairallah and Nicholas Jones and Ilknur Tugal-Tutkun and Kalpana Babu and Soumayava Basu and Richard Lee and Hassan Al-Dhibi and Bahram Bodaghi and Alessandro Invernizzi and Goldstein, {Debra A.} and Herbort, {Carl P.} and Talin Barisani-Asenbauer and Gonz{\'a}lez-L{\'o}pez, {Julio J.} and Sofia Androudi and Reema Bansal and Bruttendu Moharana and Sarakshi Mahajan and Simona Esposti and Anastasia Tasiopoulou and Sengal Nadarajah and Mamta Agarwal and Sharanya Abraham and Ruchi Vala and Joanne Lord and Ramandeep Singh and Aman Sharma and Kusum Sharma and Manfred Zierhut and Kon, {Onn Min} and John Kempen and Cunningham, {Emmett T.} and Andres Rousselot and Nguyen, {Quan Dong} and Carlos Pavesio and Vishali Gupta",
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T1 - The Collaborative Ocular Tuberculosis Study (COTS)-1

T2 - A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis

AU - Agrawal, Rupesh

AU - Gunasekeran, Dinesh Visva

AU - Agarwal, Aniruddha

AU - Carreño, Ester

AU - Aggarwal, Kanika

AU - Gupta, Bhaskar

AU - Raje, Dhananjay

AU - Murthy, Somasheila I.

AU - Westcott, Mark

AU - Chee, Soon Phaik

AU - McCluskey, Peter

AU - Ling, Ho Su

AU - Teoh, Stephen

AU - Cimino, Luca

AU - Biswas, Jyotirmay

AU - Narain, Shishir

AU - Agarwal, Manisha

AU - Mahendradas, Padmamalini

AU - Khairallah, Moncef

AU - Jones, Nicholas

AU - Tugal-Tutkun, Ilknur

AU - Babu, Kalpana

AU - Basu, Soumayava

AU - Lee, Richard

AU - Al-Dhibi, Hassan

AU - Bodaghi, Bahram

AU - Invernizzi, Alessandro

AU - Goldstein, Debra A.

AU - Herbort, Carl P.

AU - Barisani-Asenbauer, Talin

AU - González-López, Julio J.

AU - Androudi, Sofia

AU - Bansal, Reema

AU - Moharana, Bruttendu

AU - Mahajan, Sarakshi

AU - Esposti, Simona

AU - Tasiopoulou, Anastasia

AU - Nadarajah, Sengal

AU - Agarwal, Mamta

AU - Abraham, Sharanya

AU - Vala, Ruchi

AU - Lord, Joanne

AU - Singh, Ramandeep

AU - Sharma, Aman

AU - Sharma, Kusum

AU - Zierhut, Manfred

AU - Kon, Onn Min

AU - Kempen, John

AU - Cunningham, Emmett T.

AU - Rousselot, Andres

AU - Nguyen, Quan Dong

AU - Pavesio, Carlos

AU - Gupta, Vishali

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Purpose: To contribute a global description of the spectrum of choroidal involvement in tubercular uveitis (TBU). Methods: Retrospective cohort study of TBU patients with choroidal involvement from 25 centers between January 2004 and December 2014. Medical records of patients with a minimum follow-up of 1 year were reviewed. Results: 245 patients were included. The phenotypic variations included serpiginous-like choroiditis (SLC) (46%), tuberculoma (13.5%), multifocal choroiditis (MFC) (9.4%), ampiginous choroiditis (9%), among others. 219 patients were treated with anti-tubercular therapy (ATT) (n = 219/245, 89.38%), 229 patients with steroids (n = 229/245, 93.47%) and 28 patients with immunosuppressive agents (n = 28/245, 11.42%). Treatment failure was noted in 38 patients (n = 38/245, 15.5%). Patients with SLC and ampiginous choroiditis appeared to have superior outcomes on survival analysis (p = 0.06). Conclusion: This study provides a comprehensive description of choroidal involvement in TBU. Patients with SLC and ampiginous choroiditis may have better clinical outcomes.

AB - Purpose: To contribute a global description of the spectrum of choroidal involvement in tubercular uveitis (TBU). Methods: Retrospective cohort study of TBU patients with choroidal involvement from 25 centers between January 2004 and December 2014. Medical records of patients with a minimum follow-up of 1 year were reviewed. Results: 245 patients were included. The phenotypic variations included serpiginous-like choroiditis (SLC) (46%), tuberculoma (13.5%), multifocal choroiditis (MFC) (9.4%), ampiginous choroiditis (9%), among others. 219 patients were treated with anti-tubercular therapy (ATT) (n = 219/245, 89.38%), 229 patients with steroids (n = 229/245, 93.47%) and 28 patients with immunosuppressive agents (n = 28/245, 11.42%). Treatment failure was noted in 38 patients (n = 38/245, 15.5%). Patients with SLC and ampiginous choroiditis appeared to have superior outcomes on survival analysis (p = 0.06). Conclusion: This study provides a comprehensive description of choroidal involvement in TBU. Patients with SLC and ampiginous choroiditis may have better clinical outcomes.

KW - Anti-tubercular therapy

KW - choroiditis

KW - ocular

KW - tuberculosis

KW - uveitis

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