TY - JOUR
T1 - The combined effect of adiponectin and resistin on all-cause mortality in patients with type 2 diabetes
T2 - Evidence of synergism with abdominal adiposity
AU - Ortega Moreno, Lorena
AU - Lamacchia, Olga
AU - Fontana, Andrea
AU - Copetti, Massimiliano
AU - Salvemini, Lucia
AU - De Bonis, Concetta
AU - Cignarelli, Mauro
AU - Trischitta, Vincenzo
AU - Menzaghi, Claudia
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Background and aims: While elevated serum adiponectin and resistin levels have been singly associated with all-cause mortality in patients with type 2 diabetes (T2D), their combined effect has never been studied.We investigated such joint effect in patients with T2D and its possible modulation by several demographic and clinical conditions, known to affect per se mortality rate. Methods: Patients with T2D from the Gargano Mortality Study (GMS; N = 895, follow-up = 10.5 ± 3.7 years; 290 events) and the Foggia Mortality Study (FMS; N = 519, follow-up = 7.1 ± 2.5 years; 140 events) were examined. Results: As singly considered, adiponectin and resistin were independently associated with mortality rate in GMS and FMS (p <0.0001 for both). The two studies were then pooled, for investigating the nature of the joint effect of the two adipokines. In such sample, both adipokines were associated with death, independent of each other and of several additional covariates (p = 0.01-4.58 × 10-12). Of note, no adiponectin-by-resistin interaction was observed (p = 0.40), thus pointing to an additive effect of the two adipokines. As compared to individuals with low levels of both adiponectin and resistin (i.e. below median values), those with high levels of both adipokines had an HR (95%CI) for death of 3.02 (2.26-4.03). Such increased risk was more pronounced in individuals with relatively low abdominal adiposity (p for HR heterogeneity below or above the median value of waist circumference = 0.03). Conclusions: Adiponectin and resistin show an additive independent effect on all-cause mortality in patients with T2D. Such effect is modified by abdominal adiposity.
AB - Background and aims: While elevated serum adiponectin and resistin levels have been singly associated with all-cause mortality in patients with type 2 diabetes (T2D), their combined effect has never been studied.We investigated such joint effect in patients with T2D and its possible modulation by several demographic and clinical conditions, known to affect per se mortality rate. Methods: Patients with T2D from the Gargano Mortality Study (GMS; N = 895, follow-up = 10.5 ± 3.7 years; 290 events) and the Foggia Mortality Study (FMS; N = 519, follow-up = 7.1 ± 2.5 years; 140 events) were examined. Results: As singly considered, adiponectin and resistin were independently associated with mortality rate in GMS and FMS (p <0.0001 for both). The two studies were then pooled, for investigating the nature of the joint effect of the two adipokines. In such sample, both adipokines were associated with death, independent of each other and of several additional covariates (p = 0.01-4.58 × 10-12). Of note, no adiponectin-by-resistin interaction was observed (p = 0.40), thus pointing to an additive effect of the two adipokines. As compared to individuals with low levels of both adiponectin and resistin (i.e. below median values), those with high levels of both adipokines had an HR (95%CI) for death of 3.02 (2.26-4.03). Such increased risk was more pronounced in individuals with relatively low abdominal adiposity (p for HR heterogeneity below or above the median value of waist circumference = 0.03). Conclusions: Adiponectin and resistin show an additive independent effect on all-cause mortality in patients with T2D. Such effect is modified by abdominal adiposity.
KW - Additive effect
KW - Adiponectin
KW - Mortality risk
KW - Resistin
KW - Waist circumference
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U2 - 10.1016/j.atherosclerosis.2016.04.028
DO - 10.1016/j.atherosclerosis.2016.04.028
M3 - Article
AN - SCOPUS:84965176458
VL - 250
SP - 23
EP - 29
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
ER -