The combined effect of dynamic conditioning followed by fluid shear stress on an EC-SMC collagen gel co-culture

Barbara Imberti, Dror Seliktar, Andrea Remuzzi, Giuseppe Remuzzi, Robert M. Nerem

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cell-mediated effects of cyclic circumferential stretch followed by fluid shear stress on an endothelial cell (EC) and smooth muscle cell (SMC) seeded collagen gel construct. Human aortic SMCs were seeded into a reconstituted type I collagen gel for form a tubular construct. The tubes were then exposed to 10% cyclic stretch for two days using a bioreactor system. Human aortic ECs were seeded onto the lumenal surface of the tubes and exposed to laminar flow for 48 hours. It was observed that conditioned constructs showed circumferentially oriented SMCs and collagen fibrils.

Original languageEnglish
Title of host publicationSecond Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling
Pages57
Number of pages1
Publication statusPublished - 2000
EventSecond Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling - York, United Kingdom
Duration: Jul 16 2000Jul 19 2000

Other

OtherSecond Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling
CountryUnited Kingdom
CityYork
Period7/16/007/19/00

ASJC Scopus subject areas

  • Engineering(all)

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