The combined insulin and sulfonylurea therapy in diabetes of elderly people

A. Quatraro, G. Consoli, A. Minei, D. Pinto, A. Ceriello, M. Varricchio, D. Giugliano

Research output: Contribution to journalArticle


The usefulness and safety of the combined insulin-sulfonylurea (gliclazide) therapy were investigated in 70 elderly diabetic patients poorly controlled by insulin alone. More than half (45 diabetics, 64% of total) ameliorated significantly their metabolic control after six months of the combined treatment: not only the glycemic profile and glycated hemoglobin Alc were significantly decreased, but the daily insulin dose was reduced by approx. 35% (p <0.01). These positive results in terms of improved glycemic control as well as reduction of daily insulin needs were still present after a mean period of follow-up of 5 years. The good percentage of positive results, the small incidence of hypoglycemic episodes and the consistent reduction of peripheral hyperinsulinism make this intervention (insulin-gliclazide) a safe strategy that can be adopted in a population of elderly diabetics, poorly controlled on insulin alone.

Original languageEnglish
Pages (from-to)245-253
Number of pages9
JournalArchives of Gerontology and Geriatrics
Issue number3
Publication statusPublished - 1991


  • Combination therapy
  • Elderly diabetes
  • Insulin-gliclazide
  • Secondary failure

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

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