Abstract
The Purkinje cells of the cerebellar cortex are subdivided into multiple different molecular phenotypes that form an elaborate array of parasagittal stripes. This array serves as a scaffold around which afferent topography is organized. The ways in which cerebellar interneurons may be restricted by this scaffolding are less well understood. This review begins with a brief survey of cerebellar topography. Next, it reviews the development of stripes in the cerebellum with a particular emphasis on the embryological origins of cerebellar interneurons. These data serve as a foundation to discuss the hypothesis that cerebellar compartment boundaries also restrict cerebellar interneurons, both excitatory (granule cells, unipolar brush cells) and inhibitory (e.g., Golgi cells, basket cells). Finally, it is proposed that the same Purkinje cell scaffold that restricts afferent terminal fields to stripes may also act to organize cerebellar interneurons.
| Original language | English |
|---|---|
| Journal | Frontiers in Neural Circuits |
| Issue number | DEC |
| DOIs | |
| Publication status | Published - Dec 26 2012 |
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ASJC Scopus subject areas
- Neuroscience (miscellaneous)
- Cellular and Molecular Neuroscience
- Sensory Systems
- Cognitive Neuroscience
Cite this
The compartmental restriction of cerebellar interneurons. / Giacomo Consalez, G.; Hawkes, Richard.
In: Frontiers in Neural Circuits, No. DEC, 26.12.2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The compartmental restriction of cerebellar interneurons
AU - Giacomo Consalez, G.
AU - Hawkes, Richard
PY - 2012/12/26
Y1 - 2012/12/26
N2 - The Purkinje cells of the cerebellar cortex are subdivided into multiple different molecular phenotypes that form an elaborate array of parasagittal stripes. This array serves as a scaffold around which afferent topography is organized. The ways in which cerebellar interneurons may be restricted by this scaffolding are less well understood. This review begins with a brief survey of cerebellar topography. Next, it reviews the development of stripes in the cerebellum with a particular emphasis on the embryological origins of cerebellar interneurons. These data serve as a foundation to discuss the hypothesis that cerebellar compartment boundaries also restrict cerebellar interneurons, both excitatory (granule cells, unipolar brush cells) and inhibitory (e.g., Golgi cells, basket cells). Finally, it is proposed that the same Purkinje cell scaffold that restricts afferent terminal fields to stripes may also act to organize cerebellar interneurons.
AB - The Purkinje cells of the cerebellar cortex are subdivided into multiple different molecular phenotypes that form an elaborate array of parasagittal stripes. This array serves as a scaffold around which afferent topography is organized. The ways in which cerebellar interneurons may be restricted by this scaffolding are less well understood. This review begins with a brief survey of cerebellar topography. Next, it reviews the development of stripes in the cerebellum with a particular emphasis on the embryological origins of cerebellar interneurons. These data serve as a foundation to discuss the hypothesis that cerebellar compartment boundaries also restrict cerebellar interneurons, both excitatory (granule cells, unipolar brush cells) and inhibitory (e.g., Golgi cells, basket cells). Finally, it is proposed that the same Purkinje cell scaffold that restricts afferent terminal fields to stripes may also act to organize cerebellar interneurons.
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UR - http://www.scopus.com/inward/citedby.url?scp=84872069003&partnerID=8YFLogxK
U2 - 10.3389/fncir.2012.00123
DO - 10.3389/fncir.2012.00123
M3 - Article
C2 - 23346049
AN - SCOPUS:84872069003
JO - Frontiers in Neural Circuits
JF - Frontiers in Neural Circuits
SN - 1662-5110
IS - DEC
ER -