The COMT Val

Sara Poletti, Elena Mazza, Irene Bollettini, Andrea Falini, Enrico Smeraldi, Roberto Cavallaro, Francesco Benedetti

Research output: Contribution to journalArticle


Objectives Impaired cognitive functioning is a core feature of schizophrenia. Cognitive impairment in schizophrenia has been associated with white-matter (WM) abnormalities and degenerative changes of cortical myelin in the cerebral cortex. Furthermore, findings suggested a role of the COMT gene in affecting both WM and neuropsychological performances. We thus hypothesized that the COMT Val158Met genotype would affect the association between cognitive functions and WM microstructure in a sample of schizophrenic patients. Materials and methods Seventy-eight schizophrenic patients performed the brief assessment of cognition in schizophrenia for assessment of cognitive performances. Sixty-nine patients provided a venous blood sample for genotypic analysis. WM integrity was evaluated using tractbased spatial statistics with threshold-free cluster enhancement (P
Original languageEnglish
Pages (from-to)193 - 202
Number of pages10
JournalPsychiatric Genetics
Issue number5
Publication statusPublished - 2016


  • COMT
  • speed of information processing
  • TBSS schizophrenia executive function
  • white matter

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry

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  • Cite this

    Poletti, S., Mazza, E., Bollettini, I., Falini, A., Smeraldi, E., Cavallaro, R., & Benedetti, F. (2016). The COMT Val. Psychiatric Genetics, 26(5), 193 - 202.