The COMT Val158Met polymorphism moderates the association between cognitive functions and white matter microstructure in schizophrenia

Sara Poletti, Elena Mazza, Irene Bollettini, Andrea Falini, Enrico Smeraldi, Roberto Cavallaro, Francesco Benedetti

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

OBJECTIVES: Impaired cognitive functioning is a core feature of schizophrenia. Cognitive impairment in schizophrenia has been associated with white-matter (WM) abnormalities and degenerative changes of cortical myelin in the cerebral cortex. Furthermore, findings suggested a role of the COMT gene in affecting both WM and neuropsychological performances.We thus hypothesized that the COMT ValMet genotype would affect the association between cognitive functions and WM microstructure in a sample of schizophrenic patients. MATERIALS AND METHODS: Seventy-eight schizophrenic patients performed the brief assessment of cognition in schizophrenia for assessment of cognitive performances. Sixty-nine patients provided a venous blood sample for genotypic analysis. WM integrity was evaluated using tract-based spatial statistics with threshold-free cluster enhancement (P

Original languageEnglish
JournalPsychiatric Genetics
DOIs
Publication statusAccepted/In press - Mar 18 2016

Fingerprint

Cognition
Schizophrenia
Myelin Sheath
Cerebral Cortex
Genotype
White Matter
Genes

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Genetics
  • Biological Psychiatry

Cite this

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AU - Poletti, Sara

AU - Mazza, Elena

AU - Bollettini, Irene

AU - Falini, Andrea

AU - Smeraldi, Enrico

AU - Cavallaro, Roberto

AU - Benedetti, Francesco

PY - 2016/3/18

Y1 - 2016/3/18

N2 - OBJECTIVES: Impaired cognitive functioning is a core feature of schizophrenia. Cognitive impairment in schizophrenia has been associated with white-matter (WM) abnormalities and degenerative changes of cortical myelin in the cerebral cortex. Furthermore, findings suggested a role of the COMT gene in affecting both WM and neuropsychological performances.We thus hypothesized that the COMT ValMet genotype would affect the association between cognitive functions and WM microstructure in a sample of schizophrenic patients. MATERIALS AND METHODS: Seventy-eight schizophrenic patients performed the brief assessment of cognition in schizophrenia for assessment of cognitive performances. Sixty-nine patients provided a venous blood sample for genotypic analysis. WM integrity was evaluated using tract-based spatial statistics with threshold-free cluster enhancement (P

AB - OBJECTIVES: Impaired cognitive functioning is a core feature of schizophrenia. Cognitive impairment in schizophrenia has been associated with white-matter (WM) abnormalities and degenerative changes of cortical myelin in the cerebral cortex. Furthermore, findings suggested a role of the COMT gene in affecting both WM and neuropsychological performances.We thus hypothesized that the COMT ValMet genotype would affect the association between cognitive functions and WM microstructure in a sample of schizophrenic patients. MATERIALS AND METHODS: Seventy-eight schizophrenic patients performed the brief assessment of cognition in schizophrenia for assessment of cognitive performances. Sixty-nine patients provided a venous blood sample for genotypic analysis. WM integrity was evaluated using tract-based spatial statistics with threshold-free cluster enhancement (P

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