The concept of baby lung

Luciano Gattinoni, Antonio Pesenti

Research output: Chapter in Book/Report/Conference proceedingChapter


Background: The baby lung concept originated as an offspring of computed tomography examinations which showed in most patients with acute lung injury/acute respiratory distress syndrome that the normally aerated tissue has the dimensions of the lung of a 5- to 6-year-old child (300-500 g aerated tissue). Discussion: The respiratory system compliance is linearly related to the baby lung dimensions, suggesting that the acute respiratory distress syndrome lung is not stiff but instead small, with nearly normal intrinsic elasticity. Initially we taught that the baby lung is a distinct anatomical structure, in the nondependent lung regions. However, the density redistribution in prone position shows that the baby lung is a functional and not an anatomical concept. This provides a rational for gentle lung treatment and a background to explain concepts such as baro- and volutrauma. Conclusions: From a physiological perspective the baby lung helps to understand ventilator-induced lung injury. In this context, what appears dangerous is not the VT/kg ratio but instead the VT/baby lung ratio. The practical message is straightforward: the smaller the baby lung, the greater is the potential for unsafe mechanical ventilation.

Original languageEnglish
Title of host publicationApplied Physiology in Intensive Care Medicine
PublisherSpringer Berlin Heidelberg
Number of pages9
ISBN (Print)3540373616, 9783540373612
Publication statusPublished - 2006


  • Acute respiratory distress syndrome
  • Baby lung
  • Baro-/volutrauma
  • Mechanical ventilation
  • Respiratory system compliance
  • Ventilator-induced lung injury

ASJC Scopus subject areas

  • Medicine(all)


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