The concept of risk and the value of novel markers of acute kidney injury

Claudio Ronco, Zaccaria Ricci

Research output: Contribution to journalArticlepeer-review

Abstract

Kashani and colleagues studied two novel markers, insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinases-2, in the urine of patients at high risk of acute kidney injury (AKI). They validated these markers in a separate large multicenter study and compared them with known markers of AKI such as neutrophil gelatinase-associated lipocalin and kidney injury molecule-1. Insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinases-2 performed better than other known markers and their combination provided additional information. These markers could be useful in clinical practice to uncover silent episodes of AKI or to make an early identification of patients at risk. Ultimately they could help to detect and possibly prevent episodes of acute injury to the kidney, sometimes referred to as kidney attack.

Original languageEnglish
Article number117
JournalCritical Care
Volume17
Issue number1
DOIs
Publication statusPublished - Feb 13 2013

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Fingerprint Dive into the research topics of 'The concept of risk and the value of novel markers of acute kidney injury'. Together they form a unique fingerprint.

Cite this