Concetto di stress e ruolo del corticotropin-releasing factor (CRF) ipotalamico ed extraipotalamico nell'integrazione della risposta neuroendocrina ed immunitaria. Aspetti clinici e sperimentali.

Translated title of the contribution: The concept of stress and the role of hypothalamic and extra-hypothalamic corticotropin-releasing factor (CRF) in the integration of the neuroendocrine and immune responses. Clinical and experimental aspects

P. L. Puri, A. Palma, A. Fabbri

Research output: Contribution to journalArticlepeer-review

Abstract

Several evidences suggest the existence of a bidirectional link between the immune and neuroendocrine systems. This relationship explains how a "non cognitive" stimulus (as antigen) can activate the neuroendocrine axis through the inflammatory substances (cytokines) in the same manner as a stress response. A disregulation of this response can determine the basis for a pathological situation. The key-peptide of the stress response is hypothalamic CRF, though also extra-hypothalamic sources, such as the cells of the immune system, are present and could play an important role in the peripheral regulation of stress response.

Translated title of the contributionThe concept of stress and the role of hypothalamic and extra-hypothalamic corticotropin-releasing factor (CRF) in the integration of the neuroendocrine and immune responses. Clinical and experimental aspects
Original languageItalian
Pages (from-to)19-28
Number of pages10
JournalMinerva Endocrinologica
Volume19
Issue number1
Publication statusPublished - Mar 1994

ASJC Scopus subject areas

  • Medicine(all)

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