Abstract
Several evidences suggest the existence of a bidirectional link between the immune and neuroendocrine systems. This relationship explains how a "non cognitive" stimulus (as antigen) can activate the neuroendocrine axis through the inflammatory substances (cytokines) in the same manner as a stress response. A disregulation of this response can determine the basis for a pathological situation. The key-peptide of the stress response is hypothalamic CRF, though also extra-hypothalamic sources, such as the cells of the immune system, are present and could play an important role in the peripheral regulation of stress response.
| Original language | Italian |
|---|---|
| Pages (from-to) | 19-28 |
| Number of pages | 10 |
| Journal | Minerva Endocrinologica |
| Volume | 19 |
| Issue number | 1 |
| Publication status | Published - Mar 1994 |
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ASJC Scopus subject areas
- Medicine(all)
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Concetto di stress e ruolo del corticotropin-releasing factor (CRF) ipotalamico ed extraipotalamico nell'integrazione della risposta neuroendocrina ed immunitaria. Aspetti clinici e sperimentali. / Puri, P. L.; Palma, A.; Fabbri, A.
In: Minerva Endocrinologica, Vol. 19, No. 1, 03.1994, p. 19-28.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Concetto di stress e ruolo del corticotropin-releasing factor (CRF) ipotalamico ed extraipotalamico nell'integrazione della risposta neuroendocrina ed immunitaria. Aspetti clinici e sperimentali.
AU - Puri, P. L.
AU - Palma, A.
AU - Fabbri, A.
PY - 1994/3
Y1 - 1994/3
N2 - Several evidences suggest the existence of a bidirectional link between the immune and neuroendocrine systems. This relationship explains how a "non cognitive" stimulus (as antigen) can activate the neuroendocrine axis through the inflammatory substances (cytokines) in the same manner as a stress response. A disregulation of this response can determine the basis for a pathological situation. The key-peptide of the stress response is hypothalamic CRF, though also extra-hypothalamic sources, such as the cells of the immune system, are present and could play an important role in the peripheral regulation of stress response.
AB - Several evidences suggest the existence of a bidirectional link between the immune and neuroendocrine systems. This relationship explains how a "non cognitive" stimulus (as antigen) can activate the neuroendocrine axis through the inflammatory substances (cytokines) in the same manner as a stress response. A disregulation of this response can determine the basis for a pathological situation. The key-peptide of the stress response is hypothalamic CRF, though also extra-hypothalamic sources, such as the cells of the immune system, are present and could play an important role in the peripheral regulation of stress response.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028390832&partnerID=8YFLogxK
M3 - Articolo
VL - 19
SP - 19
EP - 28
JO - Minerva Endocrinologica
JF - Minerva Endocrinologica
SN - 0391-1977
IS - 1
ER -