The configuration of bi-level ventilator circuits may affect compensation for non-intentional leaks during volume-targeted ventilation

Annalisa Carlucci, Annia Schreiber, Alessio Mattei, Alberto Malovini, Jacopo Bellinati, Piero Ceriana, Cesare Gregoretti

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To assess the behaviour of a pressure-preset volume-guaranteed (VTG) mode of ventilation in the presence of non-intentional leaks in single-limb circuit (SLC) home ventilators. Methods: All SLC home ventilators commercially available in Italy can be used in a VTG mode with an intentional leak ("vented") or a true expiratory valve ("non-vented") configuration were selected. Using an experimental model consisting of a mannequin connected to an active lung simulator, for each level of leak (15, 25 and 37 l/min) three different conditions of respiratory mechanics (normal, restrictive and obstructive) were simulated using the ventilators in either a "vented" or "non-vented" configuration. Results: Three home ventilators were tested: Vivo50 (Breas), PB560 (Covidien) and Ventilogic LS (Weimann). In a "vented" circuit configuration all three ventilators kept constant or increased inspiratory pressure in all leak conditions to guarantee the VTG. Conversely, in a "non-vented" circuit configuration, all tested ventilators showed a drop in inspiratory pressure in all leak conditions, resulting in a concomitant reduction in delivered tidal volume. The same behaviour was found in all conditions of respiratory mechanics. In the absence of leaks, all the ventilators, independently of circuit configuration, were able to maintain the set VTG in the presence of modifications of the respiratory mechanics. Conclusions: The ability of the VTG mode to compensate for non-intentional leaks depends strictly on whether a "vented" or "non-vented" circuit configuration is used. This difference must be taken into account as a possible risk when a VTG mode is used in the presence of non-intentional leaks.

Original languageEnglish
Pages (from-to)59-65
Number of pages7
JournalIntensive Care Medicine
Volume39
Issue number1
DOIs
Publication statusPublished - Jan 2013

Keywords

  • Home ventilators
  • Leaks
  • Non-invasive ventilation
  • Single-limb circuit
  • Volume target

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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