The CONNECT project: Combining macro- and micro-structure

Yaniv Assaf, Daniel C. Alexander, Derek K. Jones, Albero Bizzi, Tim E J Behrens, Chris A. Clark, Yoram Cohen, Tim B. Dyrby, Petra S. Huppi, Thomas R. Knoesche, Denis LeBihan, Geoff J M Parker, Cyril Poupon, Debbie Anaby, Alfred Anwander, Leah Bar, Daniel Barazany, Tamar Blumenfeld-Katzir, Silvia De-Santis, Delphine DuclapMatteo Figini, Elda Fischi, Pamela Guevara, Penny Hubbard, Shir Hofstetter, Saad Jbabdi, Nicolas Kunz, Francois Lazeyras, Alice Lebois, Matthew G. Liptrot, Henrik Lundell, Jean Franc Mangin cedil;ois, David Moreno Dominguez, Darya Morozov, Jan Schreiber, Kiran Seunarine, Simone Nava, Till Riffert, Efrat Sasson, Benoit Schmitt, Noam Shemesh, Stam N. Sotiropoulos, Ido Tavor, Hui Zhang, Feng Lei Zhou

Research output: Contribution to journalArticle

Abstract

In recent years, diffusion MRI has become an extremely important tool for studying the morphology of living brain tissue, as it provides unique insights into both its macrostructure and microstructure. Recent applications of diffusion MRI aimed to characterize the structural connectome using tractography to infer connectivity between brain regions. In parallel to the development of tractography, additional diffusion MRI based frameworks (CHARMED, AxCaliber, ActiveAx) were developed enabling the extraction of a multitude of micro-structural parameters (axon diameter distribution, mean axonal diameter and axonal density). This unique insight into both tissue microstructure and connectivity has enormous potential value in understanding the structure and organization of the brain as well as providing unique insights to abnormalities that underpin disease states.The CONNECT (Consortium Of Neuroimagers for the Non-invasive Exploration of brain Connectivity and Tracts) project aimed to combine tractography and micro-structural measures of the living human brain in order to obtain a better estimate of the connectome, while also striving to extend validation of these measurements. This paper summarizes the project and describes the perspective of using micro-structural measures to study the connectome.

Original languageEnglish
Pages (from-to)273-282
Number of pages10
JournalNeuroImage
Volume80
DOIs
Publication statusPublished - Oct 15 2013

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

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  • Cite this

    Assaf, Y., Alexander, D. C., Jones, D. K., Bizzi, A., Behrens, T. E. J., Clark, C. A., Cohen, Y., Dyrby, T. B., Huppi, P. S., Knoesche, T. R., LeBihan, D., Parker, G. J. M., Poupon, C., Anaby, D., Anwander, A., Bar, L., Barazany, D., Blumenfeld-Katzir, T., De-Santis, S., ... Zhou, F. L. (2013). The CONNECT project: Combining macro- and micro-structure. NeuroImage, 80, 273-282. https://doi.org/10.1016/j.neuroimage.2013.05.055