The contribution of cell phenotype to the behavior of gastric cancer

Enrico Solcia, Catherine Klersy, Alessandro Vanoli, Federica Grillo, Rachele Manca, Francesca Tava, Ombretta Luinetti, Roberto Fiocca

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Several histochemical studies suggest a role of tumor cell phenotype and related differentiation markers in the prognostic assessment of gastric cancer. Unfortunately, most studies have dealt with single or a few markers and have paid limited attention to their interplay with tumor histological types, which are potentially informative of prognosis. Methods: In this study, 292 invasive (T1b to T4) gastric cancers with prolonged follow-up and carefully analyzed histotype, inclusive of histotype-based grade, were investigated histochemically with a panel of 14 phenotypic markers known to be expressed in normal gut tissues and gastric cancer. Results: Three of seven intestinal type markers investigated showed a trend for improved prognosis, one of which, CDX2, was stage independent. Three among gastric and pancreatobiliary duct markers (MUC1, MUC6, and pepsinogen II), predicted more severe prognosis stage independently, as did a combination of eight potentially informative (p <0.1 at univariable Cox analysis) markers. Cancers with predominantly intestinal phenotype had significantly better prognosis than those with predominantly gastric, mixed, or poorly defined phenotypes; among the latter, those with high lymphocyte response, with favorable outcome, were separated from anaplastic cancers, with ominous prognosis. At multivariable analysis, CDX2 and the eight marker combination proved to be stage- and grade-independent predictors. Conclusions: When individually considered, and with the exception of CDX2, the biomarkers investigated gave an appreciable, although moderate, contribution to the prognostic evaluation of gastric cancer. Combined analysis of all potentially informative markers gave more important information, highly additive to both stage and histotype-based grade.

Original languageEnglish
Pages (from-to)462-471
Number of pages10
JournalGastric Cancer
Volume16
Issue number4
DOIs
Publication statusPublished - Oct 2013

Keywords

  • Gastric cancer
  • Histotype
  • Phenotypic markers
  • Prognosis
  • Tumor cell phenotype

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology
  • Cancer Research

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