The contribution of cerebellar proton magnetic resonance spectroscopy in the differential diagnosis among parkinsonian syndromes

Stefano Zanigni, Claudia Testa, Giovanna Calandra-Buonaura, Luisa Sambati, Maria Guarino, Anna Gabellini, Stefania Evangelisti, Pietro Cortelli, Raffaele Lodi, Caterina Tonon

Research output: Contribution to journalArticle

Abstract

Introduction: The invivo differential diagnosis between idiopathic Parkinson's disease (PD) and atypical parkinsonian syndromes (PS), such as multiple system atrophy [MSA with a cerebellar (C) and parkinsonian (P) subtype] and progressive supranuclear palsy - Richardson's Syndrome (PSP-RS) is often challenging. Previous brain MR proton spectroscopy (1H-MRS) studies showed biochemical alterations in PS, despite results are conflicting. Cerebellum plays a central role in motor control and its alterations has been already demonstrated in atypical PS. The main aim of this study was to evaluate diagnostic accuracy of cerebellar 1H-MRS in the differential diagnosis between PD and atypical PS. Methods: We obtained 1H-MRS spectra from the left cerebellar hemisphere of 57PS (21 PD, and 36 atypical PS) and 14 unaffected controls by using a 1.5TGE scanner. N-acetyl-aspartate (NAA)/Creatine (Cr), choline-containing compounds (Cho)/Cr, myoinositol (mI)/Cr, and NAA/mI ratios were calculated. Results: NAA/Cr and NAA/mI ratios were significantly lower (p1H-MRS could represent an adjunctive diagnostic tool to improve the differential diagnosis of PS.

Original languageEnglish
Pages (from-to)929-937
Number of pages9
JournalParkinsonism and Related Disorders
Volume21
Issue number8
DOIs
Publication statusPublished - Aug 1 2015

Keywords

  • Cerebellum
  • MRS
  • Multiple system atrophy
  • Parkinson's disease
  • Progressive supranuclear palsy

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology

Fingerprint Dive into the research topics of 'The contribution of cerebellar proton magnetic resonance spectroscopy in the differential diagnosis among parkinsonian syndromes'. Together they form a unique fingerprint.

  • Cite this