The observation, by Furchgott and Zawadzki, that a factor of short average life, released by endothelial cells accounted for vasodilation was the beginning of one of the most fascinating adventures in the recent history of science. The discovery that this released factor was nitric oxide had tremendous implications for our understanding not only of the homeostasis of the vascular tissue, but also of a variety of other biological processes ranging from synaptic plasticity to regulation of immune responses. This review article will lead the reader through the landmark events in this adventure, highlighting the fundamental role played by Salvador Moncada and his team.
- Endothelium-Derived Relaxing Factor
- Guanylate cyclase, cytochrome c oxidase, mitochondria, apoptosis
- Nitric oxide
- Salvador Moncada
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology