The control of gene expression in macrophages

Renato Ostuni; Gioacchino Natoli

doi:10.1007/978-1-4939-1311-4_26

The control of gene expression in macrophages

Renato Ostuni, Gioacchino Natoli

Istituto Europeo di Oncologia

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Recent advances in high-throughput genomic technologies have allowed the definition of some fundamental principles underlying chromatin-mediated regulation of gene expression. In this context, macrophages have emerged as a paradigmatic cell population, whose analysis yielded principles widely applicable to multiple cellular systems. In this chapter we discuss the epigenetic and chromatin determinants of inducible transcription in macrophages, and how developmental and environmental inputs integrate at noncoding cis-regulatory elements to determine context-dependent gene expression. The resulting models provide a conceptual framework to understand the transcriptional foundations of macrophage functions in physiology and disease.

Original language	English
Title of host publication	Macrophages: Biology and Role in the Pathology of Diseases
Publisher	Springer New York
Pages	519-543
Number of pages	25
ISBN (Print)	9781493913114, 1493913107, 9781493913107
DOIs	https://doi.org/10.1007/978-1-4939-1311-4_26
Publication status	Published - May 1 2014

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ASJC Scopus subject areas

Medicine(all)
Immunology and Microbiology(all)

Cite this

Ostuni, R., & Natoli, G. (2014). The control of gene expression in macrophages. In Macrophages: Biology and Role in the Pathology of Diseases (pp. 519-543). Springer New York. https://doi.org/10.1007/978-1-4939-1311-4_26

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10.1007/978-1-4939-1311-4_26