The control of gene expression in macrophages

Renato Ostuni, Gioacchino Natoli

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Recent advances in high-throughput genomic technologies have allowed the definition of some fundamental principles underlying chromatin-mediated regulation of gene expression. In this context, macrophages have emerged as a paradigmatic cell population, whose analysis yielded principles widely applicable to multiple cellular systems. In this chapter we discuss the epigenetic and chromatin determinants of inducible transcription in macrophages, and how developmental and environmental inputs integrate at noncoding cis-regulatory elements to determine context-dependent gene expression. The resulting models provide a conceptual framework to understand the transcriptional foundations of macrophage functions in physiology and disease.

Original languageEnglish
Title of host publicationMacrophages: Biology and Role in the Pathology of Diseases
PublisherSpringer New York
Pages519-543
Number of pages25
ISBN (Print)9781493913114, 1493913107, 9781493913107
DOIs
Publication statusPublished - May 1 2014

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ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Ostuni, R., & Natoli, G. (2014). The control of gene expression in macrophages. In Macrophages: Biology and Role in the Pathology of Diseases (pp. 519-543). Springer New York. https://doi.org/10.1007/978-1-4939-1311-4_26