The conundrum of HLA-DRB1*14: 01/*14:54 and HLA-DRB3*02: 01/*02:02 mismatches in unrelated hematopoietic SCT

A. Pasi, R. Crocchiolo, M. Bontempelli, C. Carcassi, G. Carella, L. Crespiatico, L. Garbarino, L. Mascaretti, B. Mazzi, G. Mazzola, V. Miotti, B. Porfirio, C. Tagliaferri, T. Valentini, C. Vecchiato, K. Fleischhauer, N. Sacchi, A. Bosi, M. Martinetti

Research output: Contribution to journalArticle

Abstract

Uncertainty still exists on the role of polymorphisms outside the HLA-DRB1 binding site or inside the HLA-DRB3 binding groove in unrelated hematopoietic SCT (HSCT). The ideal model to solve the conundrum consists of the transplants mismatched for HLA-DRB1*14:01/*14:54 and/or for HLA-DRB3*02: 01/*02:02. A task force was set up in Italy to recruit transplanted pairs defined as HLA-DRB1*14:01 before 2006, the year crucial for the proper definition of the HLA-DRB1*14:54 allele in molecular biology. Out of 2723 unrelated pairs, 189 transplanted in Italy from 1995 to 2006 were HLA-DRB1*14:01 positive; 103/189 pairs with good historical DNA were retyped for HLA-DRB114 and HLA-DRB3 at-high resolution level; 31/103 pairs had HLA-DRB114 and/or HLA-DRB3 mismatched; 99/103, having complete clinical data, underwent statistical analysis for OS, TRM, disease-free survival and acute and chronic GvHD. No significant involvement of HLA-DRB1*14:01/*14:54 or HLA-DRB3*02:01/*02:02 mismatches was found, either alone or combined. Our findings suggest that disparities at exon 3 of the HLA-DRB1 gene seem unlikely to influence the outcome after HSCT. The same may be envisaged for HLA-DRB3 02:01 and 02:02 alleles which, although differing in the Ag binding site, seem unable to modulate an appreciable immune response in an HSCT setting.

Original languageEnglish
Pages (from-to)916-922
Number of pages7
JournalBone Marrow Transplantation
Volume46
Issue number7
DOIs
Publication statusPublished - Jul 2011

Keywords

  • HLA-DRB1 exon 3 mismatch
  • HLA-DRB3 mismatch
  • outcome
  • unrelated SCT

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Fingerprint Dive into the research topics of 'The conundrum of HLA-DRB1*14: 01/*14:54 and HLA-DRB3*02: 01/*02:02 mismatches in unrelated hematopoietic SCT'. Together they form a unique fingerprint.

  • Cite this

    Pasi, A., Crocchiolo, R., Bontempelli, M., Carcassi, C., Carella, G., Crespiatico, L., Garbarino, L., Mascaretti, L., Mazzi, B., Mazzola, G., Miotti, V., Porfirio, B., Tagliaferri, C., Valentini, T., Vecchiato, C., Fleischhauer, K., Sacchi, N., Bosi, A., & Martinetti, M. (2011). The conundrum of HLA-DRB1*14: 01/*14:54 and HLA-DRB3*02: 01/*02:02 mismatches in unrelated hematopoietic SCT. Bone Marrow Transplantation, 46(7), 916-922. https://doi.org/10.1038/bmt.2010.246