The correlation between LDH serum levels and clinical outcome in advanced biliary tract cancer patients treated with first line chemotherapy

Luca Faloppi, Michela Del Prete, Andrea Casadei Gardini, Daniele Santini, Nicola Silvestris, Maristella Bianconi, Riccardo Giampieri, Martina Valgiusti, Oronzo Brunetti, Alessandro Bittoni, Kalliopi Andrikou, Eleonora Lai, Alessandra Dessì, Stefano Cascinu, Mario Scartozzi

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Abstract

LDH may represent an indirect marker of neo-angiogenesis and worse prognosis in many tumour types. We assessed the correlation between LDH and clinical outcome for biliary tract cancer (BTC) patients treated with first-line chemotherapy. Overall, 114 advanced BTC patients treated with first-line gemcitabine and cisplatin were included. Patients were divided into two groups (low vs. high LDH), according to pre-treatment LDH values. Patients were also classified according to pre- and post-treatment variation in LDH serum levels (increased vs. decreased). Median progression free survival (PFS) was 5.0 and 2.6 months respectively in patients with low and high pre-treatment LDH levels (p = 0.0042, HR = 0.56, 95% CI: 0.37-0.87). Median overall survival (OS) was 7.7 and 5.6 months (low vs. high LDH) (p = 0.324, HR = 0.81, 95% CI: 0.54-1.24). DCR was 71% vs. 43% (low vs. high LDH) (p = 0.002). In 38 patients with decreased LDH values after treatment, PFS and OS were respectively 6.2 and 12.1 months, whereas in 76 patients with post-treatment increased LDH levels, PFS and OS were respectively 3.0 and 5.1 months (PFS: p = 0.0009; HR = 0.49; 95% IC: 0.33-0.74; OS: p <0.0001; HR = 0.42; 95% IC: 0.27-0.63). Our data seem to suggest that LDH serum level may predict clinical outcome in BTC patients receiving first-line chemotherapy.

Original languageEnglish
Article number24136
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - Apr 11 2016

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    Faloppi, L., Del Prete, M., Gardini, A. C., Santini, D., Silvestris, N., Bianconi, M., Giampieri, R., Valgiusti, M., Brunetti, O., Bittoni, A., Andrikou, K., Lai, E., Dessì, A., Cascinu, S., & Scartozzi, M. (2016). The correlation between LDH serum levels and clinical outcome in advanced biliary tract cancer patients treated with first line chemotherapy. Scientific Reports, 6, [24136]. https://doi.org/10.1038/srep24136