TY - JOUR
T1 - The cortisol burden in elderly subjects with metabolic syndrome and its association with low-grade inflammation
AU - AGICO Investigators
AU - Martocchia, Antonio
AU - Gallucci, M.
AU - Noale, Marianna
AU - Maggi, S.
AU - Cassol, Maurizio
AU - Stefanelli, Manuela
AU - Postacchini, D.
AU - Proietti, A.
AU - Barbagallo, M.
AU - Dominguez, Ligia J.
AU - Ferri, C.
AU - Desideri, Giovambattista
AU - Toussan, Lavinia
AU - Pastore, F.
AU - Falaschi, Giulia Maria
AU - Paolisso, Giuseppe
AU - Falaschi, Paolo
AU - Falaschi, Paolo
AU - Martocchia, Antonio
AU - Stefanelli, Manuela
AU - Toussan, Lavinia
AU - Pastore, Francesca
AU - Eleuteri, Stefano
AU - Falaschi, Giulia Maria
AU - Proietti, Antonella
AU - D’Urso, Rosaria
AU - Petricca, Letizia
AU - Cardelli, Patrizia
AU - Gallucci, Maurizio
AU - Oddo, Maria Grazia
AU - Maggi, Stefania
AU - Noale, Marianna
AU - Postacchini, D.
AU - Giuli, Cinzia
AU - Macchiati, Ilenia
AU - Migale, Monica
AU - Sorvillo, Francesca
AU - Brunelli, Roberto
AU - Francavilla, Monia
AU - Santini, Silvia
AU - Marini, Luciano
AU - Santillo, Elpidio
AU - Fallavollita, Luca
AU - Cassol, Maurizio
AU - Rotunno, Sara
AU - Paolisso, Giuseppe
AU - Barbieri, Michelangela
AU - Angellotti, Edith
AU - Ferri, Claudio
AU - Ludovici, Valeria
PY - 2019/8/30
Y1 - 2019/8/30
N2 - Background: Elderly people are exposed to an increased load of stressful events and neuro-hormonal stimulation is a key finding in metabolic syndrome and its related disorders. Aims: To determine the role of cortisol in elderly subjects, with or without metabolic syndrome (MetS), by means of a national multicentre observational study, AGICO (AGIng and Cortisol). Methods: From 2012 to 2017, the AGICO study enrolled n.339 subjects (aged > 65), after obtaining their informed consent. The investigators assessed a cardio-metabolic panel (including electrocardiogram, carotid ultrasonography and echocardiography), the presence of MetS (on Adult Treatment Panel III criteria), a neurological examination (including brain imaging), and cortisol activity (using a consecutive collection of diurnal and nocturnal urine). Results: In the patients presenting with MetS, the standardized diurnal and nocturnal cortisol excretion rates were 210.7 ± 145.5 and 173.7 ± 118.1 (mean ± standard deviation) μg/g creatinine/12 h; in those without MetS, the standardized diurnal and nocturnal cortisol excretion rates were 188.7 ± 92.7 and 144.1 ± 82.3 μg/g creatinine/12 h, respectively (nocturnal urinary cortisol in patients with MetS versus those without MetS p = 0.05, female patients with MetS vs female patients without MetS, p < 0.025). A significant positive correlation was found between the CRP levels and both the diurnal and nocturnal urinary cortisol levels with r = 0.187 (p < 0.025) and r = 0.411 (p < 0.00000001), respectively. Discussion: The elderly patients with MetS showed a trend towards increased standardized nocturnal cortisol excretions, with particular regard to the female subjects. Conclusion: The positive correlation between cortisol excretion and low-grade inflammation suggests a common mechanism driving both hormonal and inflammatory changes.
AB - Background: Elderly people are exposed to an increased load of stressful events and neuro-hormonal stimulation is a key finding in metabolic syndrome and its related disorders. Aims: To determine the role of cortisol in elderly subjects, with or without metabolic syndrome (MetS), by means of a national multicentre observational study, AGICO (AGIng and Cortisol). Methods: From 2012 to 2017, the AGICO study enrolled n.339 subjects (aged > 65), after obtaining their informed consent. The investigators assessed a cardio-metabolic panel (including electrocardiogram, carotid ultrasonography and echocardiography), the presence of MetS (on Adult Treatment Panel III criteria), a neurological examination (including brain imaging), and cortisol activity (using a consecutive collection of diurnal and nocturnal urine). Results: In the patients presenting with MetS, the standardized diurnal and nocturnal cortisol excretion rates were 210.7 ± 145.5 and 173.7 ± 118.1 (mean ± standard deviation) μg/g creatinine/12 h; in those without MetS, the standardized diurnal and nocturnal cortisol excretion rates were 188.7 ± 92.7 and 144.1 ± 82.3 μg/g creatinine/12 h, respectively (nocturnal urinary cortisol in patients with MetS versus those without MetS p = 0.05, female patients with MetS vs female patients without MetS, p < 0.025). A significant positive correlation was found between the CRP levels and both the diurnal and nocturnal urinary cortisol levels with r = 0.187 (p < 0.025) and r = 0.411 (p < 0.00000001), respectively. Discussion: The elderly patients with MetS showed a trend towards increased standardized nocturnal cortisol excretions, with particular regard to the female subjects. Conclusion: The positive correlation between cortisol excretion and low-grade inflammation suggests a common mechanism driving both hormonal and inflammatory changes.
KW - Aging
KW - Cortisol
KW - Inflammation
KW - Metabolic syndrome
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U2 - 10.1007/s40520-019-01322-3
DO - 10.1007/s40520-019-01322-3
M3 - Article
C2 - 31471891
AN - SCOPUS:85072048623
JO - Aging clinical and experimental research
JF - Aging clinical and experimental research
SN - 1594-0667
ER -