We analyzed the effect of pregnancy on seizure frequency in women with epilepsy (E) followed prospectively. From 1988 to 1991 we followed 164 women with E, 140 of which were term-pregnancies (24 abortion): seizure frequency was unchanged in 68%, increased in 26% and improved in 6% of pregnancies. In pts with increased seizure frequency during pregnancy, the highest increase was in the first trimester (54%); serum AED's levels were in range in 46%, below the therapeutic concentration in 43%; concerning the type of E, there was an increased seizure frequency in 29% of the pts with partial E and 17.5% of the pts with generalized idiopatic E; no difference was found between partial symptomatic (30%) and partial criptogenic (28%) E in the increase of seizure frequency. In the group of the pts affected by generalized idiopatic E we found a different risk of increased seizure frequency as follow: 7% for the pts with childhood and juvenile absence E, 17% for those with E with GTC seizures on awakening and 37.5% for those with JME.
|Translated title of the contribution||The course of epilepsy during pregnancy: A prospective study of 164 cases|
|Number of pages||3|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 1992|
ASJC Scopus subject areas
- Clinical Neurology