The Crosstalk between Cancer Stem Cells and Microenvironment Is Critical for Solid Tumor Progression: The Significant Contribution of Extracellular Vesicles

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4 Citations (Scopus)

Abstract

Several evidences nowadays demonstrated the critical role of the microenvironment in regulating cancer stem cells and their involvement in tumor progression. Extracellular vesicles (EVs) are considered as one of the most effective vehicles of information among cells. Accordingly, a number of studies led to the recognition of stem cell-associated EVs as new complexes able to contribute to cell fate determination of either normal or tumor cells. In this review, we aim to highlight an existing bidirectional role of EV-mediated communication - from cancer stem cells to microenvironment and also from microenvironment to cancer stem cells - in the most widespread solid cancers as prostate, breast, lung, and colon tumors.

Original languageEnglish
Article number6392198
JournalStem Cells International
Volume2018
DOIs
Publication statusPublished - Jan 1 2018

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Stem Cell Niche
Neoplastic Stem Cells
Neoplasms
Prostatic Neoplasms
Colon
Breast
Stem Cells
Lung
Extracellular Vesicles

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

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abstract = "Several evidences nowadays demonstrated the critical role of the microenvironment in regulating cancer stem cells and their involvement in tumor progression. Extracellular vesicles (EVs) are considered as one of the most effective vehicles of information among cells. Accordingly, a number of studies led to the recognition of stem cell-associated EVs as new complexes able to contribute to cell fate determination of either normal or tumor cells. In this review, we aim to highlight an existing bidirectional role of EV-mediated communication - from cancer stem cells to microenvironment and also from microenvironment to cancer stem cells - in the most widespread solid cancers as prostate, breast, lung, and colon tumors.",
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