The crucial role of vascular permeability factor/vascular endothelial growth factor in angiogenesis: A historical review

Domenico Ribatti

Research output: Contribution to journalArticle

Abstract

Angiogenesis is a biological process by which new capillaries are formed and it occurs in many physiological and pathological conditions. It is controlled by the net balance between molecules that have positive and negative regulatory activity and this concept had led to the notion of the 'angiogenic switch', depending on an increased production of one or more of the positive regulators of angiogenesis. Numerous inducers of angiogenesis have been identified and this review offers a historical account of the relevant literature concerning the discovery of one of the best characterized angiogenic factors, namely vascular endothelial growth factor (VEGF)/vascular permeability factor. Moreover, different strategies, designed to stimulate and to inhibit VEGF production in the context of several potential therapeutical implications, are discussed.

Original languageEnglish
Pages (from-to)303-309
Number of pages7
JournalBritish Journal of Haematology
Volume128
Issue number3
DOIs
Publication statusPublished - Feb 2005

Keywords

  • Angiogenesis
  • History of medicine
  • Vascular endothelial growth factor
  • Vascular permeability factor

ASJC Scopus subject areas

  • Hematology

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