TY - JOUR
T1 - The crucial role of vascular permeability factor/vascular endothelial growth factor in angiogenesis
T2 - A historical review
AU - Ribatti, Domenico
PY - 2005/2
Y1 - 2005/2
N2 - Angiogenesis is a biological process by which new capillaries are formed and it occurs in many physiological and pathological conditions. It is controlled by the net balance between molecules that have positive and negative regulatory activity and this concept had led to the notion of the 'angiogenic switch', depending on an increased production of one or more of the positive regulators of angiogenesis. Numerous inducers of angiogenesis have been identified and this review offers a historical account of the relevant literature concerning the discovery of one of the best characterized angiogenic factors, namely vascular endothelial growth factor (VEGF)/vascular permeability factor. Moreover, different strategies, designed to stimulate and to inhibit VEGF production in the context of several potential therapeutical implications, are discussed.
AB - Angiogenesis is a biological process by which new capillaries are formed and it occurs in many physiological and pathological conditions. It is controlled by the net balance between molecules that have positive and negative regulatory activity and this concept had led to the notion of the 'angiogenic switch', depending on an increased production of one or more of the positive regulators of angiogenesis. Numerous inducers of angiogenesis have been identified and this review offers a historical account of the relevant literature concerning the discovery of one of the best characterized angiogenic factors, namely vascular endothelial growth factor (VEGF)/vascular permeability factor. Moreover, different strategies, designed to stimulate and to inhibit VEGF production in the context of several potential therapeutical implications, are discussed.
KW - Angiogenesis
KW - History of medicine
KW - Vascular endothelial growth factor
KW - Vascular permeability factor
UR - http://www.scopus.com/inward/record.url?scp=13444261932&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13444261932&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2141.2004.05291.x
DO - 10.1111/j.1365-2141.2004.05291.x
M3 - Article
C2 - 15667531
AN - SCOPUS:13444261932
VL - 128
SP - 303
EP - 309
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 3
ER -