The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC

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Abstract

Hepatocellular carcinoma (HCC) is one of the most common human solid malignancies worldwide. Although the MRI is the technique that is best adapted to characterize HCC, there is not an agreement regarding the study protocol and even what the role of Diffusion-weighted imaging (DWI). The possibility that imaging study can correlate to histologic grade to selecting the therapeutic strategy would be valuable in helping to direct the proper management of HCC. Apparent Diffusion Coefficient (ADC) and IVIM-derived perfusion fraction (fp) and tissue diffusivity (Dt) values of HCC showed significantly better diagnostic performance in differentiating high-grade HCC from low-grade HCC, and significant correlation was observed between ADC, fp, Dt and histological grade.

Original languageEnglish
Pages (from-to)23
JournalInfectious Agents and Cancer
Volume13
DOIs
Publication statusPublished - 2018

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Hepatocellular Carcinoma
Perfusion
Neoplasms
Therapeutics

Cite this

@article{8007101dff4342dbb4bf2ac7b83aaad8,
title = "The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC",
abstract = "Hepatocellular carcinoma (HCC) is one of the most common human solid malignancies worldwide. Although the MRI is the technique that is best adapted to characterize HCC, there is not an agreement regarding the study protocol and even what the role of Diffusion-weighted imaging (DWI). The possibility that imaging study can correlate to histologic grade to selecting the therapeutic strategy would be valuable in helping to direct the proper management of HCC. Apparent Diffusion Coefficient (ADC) and IVIM-derived perfusion fraction (fp) and tissue diffusivity (Dt) values of HCC showed significantly better diagnostic performance in differentiating high-grade HCC from low-grade HCC, and significant correlation was observed between ADC, fp, Dt and histological grade.",
author = "Vincenza Granata and Roberta Fusco and Salvatore Filice and Orlando Catalano and Mauro Piccirillo and Raffaele Palaia and Francesco Izzo and Antonella Petrillo",
year = "2018",
doi = "10.1186/s13027-018-0194-5",
language = "English",
volume = "13",
pages = "23",
journal = "Infectious Agents and Cancer",
issn = "1750-9378",
publisher = "BioMed Central",

}

TY - JOUR

T1 - The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC

AU - Granata, Vincenza

AU - Fusco, Roberta

AU - Filice, Salvatore

AU - Catalano, Orlando

AU - Piccirillo, Mauro

AU - Palaia, Raffaele

AU - Izzo, Francesco

AU - Petrillo, Antonella

PY - 2018

Y1 - 2018

N2 - Hepatocellular carcinoma (HCC) is one of the most common human solid malignancies worldwide. Although the MRI is the technique that is best adapted to characterize HCC, there is not an agreement regarding the study protocol and even what the role of Diffusion-weighted imaging (DWI). The possibility that imaging study can correlate to histologic grade to selecting the therapeutic strategy would be valuable in helping to direct the proper management of HCC. Apparent Diffusion Coefficient (ADC) and IVIM-derived perfusion fraction (fp) and tissue diffusivity (Dt) values of HCC showed significantly better diagnostic performance in differentiating high-grade HCC from low-grade HCC, and significant correlation was observed between ADC, fp, Dt and histological grade.

AB - Hepatocellular carcinoma (HCC) is one of the most common human solid malignancies worldwide. Although the MRI is the technique that is best adapted to characterize HCC, there is not an agreement regarding the study protocol and even what the role of Diffusion-weighted imaging (DWI). The possibility that imaging study can correlate to histologic grade to selecting the therapeutic strategy would be valuable in helping to direct the proper management of HCC. Apparent Diffusion Coefficient (ADC) and IVIM-derived perfusion fraction (fp) and tissue diffusivity (Dt) values of HCC showed significantly better diagnostic performance in differentiating high-grade HCC from low-grade HCC, and significant correlation was observed between ADC, fp, Dt and histological grade.

U2 - 10.1186/s13027-018-0194-5

DO - 10.1186/s13027-018-0194-5

M3 - Review article

VL - 13

SP - 23

JO - Infectious Agents and Cancer

JF - Infectious Agents and Cancer

SN - 1750-9378

ER -