The cutaneous assessment tool: Development and reliability in juvenile idiopathic inflammatory myopathy

Adam M. Huber, E. M. Dugan, P. A. Lachenbruch, B. M. Feldman, M. D. Perez, L. S. Zemel, C. B. Lindsley, R. M. Rennebohm, C. A. Wallace, M. H. Passo, A. M. Reed, S. L. Bowyer, S. H. Ballinger, F. W. Miller, L. G. Rider, Robert Colbert, Jaime DeInocencio, Thomas Griffin, Philip Hashkes, Raphael HirschDeborah Kredich, Ronald Laxer, Joseph Levinson, Daniel Lovell, Nicola Ruperto, Earl Silverman, Robert Sundel, Scott Vogelgesang

Research output: Contribution to journalArticle

Abstract

Objectives. Clinical care and therapeutic trials in idiopathic inflammatory myopathies (IIM) require accurate and consistent assessment of cutaneous involvement. The Cutaneous Assessment Tool (CAT) was designed to measure skin activity and damage in IIM. We describe the development and inter-rater reliability of the CAT, and the frequency of lesions endorsed in a large population of juvenile IIM patients. Methods. The CAT includes 10 activity, 4 damage and 7 combined lesions. Thirty-two photographic slides depicting IIM skin lesions were assessed by 11 raters. One hundred and twenty-three children were assessed by 11 paediatric rheumatologists at 10 centres. Inter-rater reliability was assessed using simple agreements and intra-class correlation coefficients (ICC). Results. Simple agreements in recognizing lesions as present or absent were generally high (0.5-1.0). ICCs for CAT lesions were moderate (0.4-0.75) in both slides and real patients. ICCs for the CAT activity and damage scores were 0.71 and 0.81, respectively. CAT activity scores ranged from 0 to 44 (median 7, potential range 0-96) and CAT damage scores ranged from 0 to 13 (median 1, potential range 0-22). The most common cutaneous lesions endorsed were periungual capillary loop changes (63%), Gottron's papules/sign (53%), heliotrope rash (49%) and malar/ facial erythema (49%). Conclusions. Total CAT activity and damage scores have moderate to good reliability. Assessors generally agree on the presence of a variety of cutaneous lesions. The CAT is a promising, semi-quantitative tool to comprehensively assess skin disease activity and damage in IIM.

Original languageEnglish
Pages (from-to)1606-1611
Number of pages6
JournalRheumatology
Volume46
Issue number10
DOIs
Publication statusPublished - Oct 2007

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Myositis
Skin
Erythema
Exanthema
Skin Diseases

Keywords

  • Assessment
  • Cutaneous Assessment Tool
  • Juvenile dermatomyositis
  • Juvenile idiopathic inflammatory myopathy
  • Skin disease

ASJC Scopus subject areas

  • Neuroscience(all)
  • Rheumatology

Cite this

Huber, A. M., Dugan, E. M., Lachenbruch, P. A., Feldman, B. M., Perez, M. D., Zemel, L. S., ... Vogelgesang, S. (2007). The cutaneous assessment tool: Development and reliability in juvenile idiopathic inflammatory myopathy. Rheumatology, 46(10), 1606-1611. https://doi.org/10.1093/rheumatology/kem179

The cutaneous assessment tool : Development and reliability in juvenile idiopathic inflammatory myopathy. / Huber, Adam M.; Dugan, E. M.; Lachenbruch, P. A.; Feldman, B. M.; Perez, M. D.; Zemel, L. S.; Lindsley, C. B.; Rennebohm, R. M.; Wallace, C. A.; Passo, M. H.; Reed, A. M.; Bowyer, S. L.; Ballinger, S. H.; Miller, F. W.; Rider, L. G.; Colbert, Robert; DeInocencio, Jaime; Griffin, Thomas; Hashkes, Philip; Hirsch, Raphael; Kredich, Deborah; Laxer, Ronald; Levinson, Joseph; Lovell, Daniel; Ruperto, Nicola; Silverman, Earl; Sundel, Robert; Vogelgesang, Scott.

In: Rheumatology, Vol. 46, No. 10, 10.2007, p. 1606-1611.

Research output: Contribution to journalArticle

Huber, AM, Dugan, EM, Lachenbruch, PA, Feldman, BM, Perez, MD, Zemel, LS, Lindsley, CB, Rennebohm, RM, Wallace, CA, Passo, MH, Reed, AM, Bowyer, SL, Ballinger, SH, Miller, FW, Rider, LG, Colbert, R, DeInocencio, J, Griffin, T, Hashkes, P, Hirsch, R, Kredich, D, Laxer, R, Levinson, J, Lovell, D, Ruperto, N, Silverman, E, Sundel, R & Vogelgesang, S 2007, 'The cutaneous assessment tool: Development and reliability in juvenile idiopathic inflammatory myopathy', Rheumatology, vol. 46, no. 10, pp. 1606-1611. https://doi.org/10.1093/rheumatology/kem179
Huber, Adam M. ; Dugan, E. M. ; Lachenbruch, P. A. ; Feldman, B. M. ; Perez, M. D. ; Zemel, L. S. ; Lindsley, C. B. ; Rennebohm, R. M. ; Wallace, C. A. ; Passo, M. H. ; Reed, A. M. ; Bowyer, S. L. ; Ballinger, S. H. ; Miller, F. W. ; Rider, L. G. ; Colbert, Robert ; DeInocencio, Jaime ; Griffin, Thomas ; Hashkes, Philip ; Hirsch, Raphael ; Kredich, Deborah ; Laxer, Ronald ; Levinson, Joseph ; Lovell, Daniel ; Ruperto, Nicola ; Silverman, Earl ; Sundel, Robert ; Vogelgesang, Scott. / The cutaneous assessment tool : Development and reliability in juvenile idiopathic inflammatory myopathy. In: Rheumatology. 2007 ; Vol. 46, No. 10. pp. 1606-1611.
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abstract = "Objectives. Clinical care and therapeutic trials in idiopathic inflammatory myopathies (IIM) require accurate and consistent assessment of cutaneous involvement. The Cutaneous Assessment Tool (CAT) was designed to measure skin activity and damage in IIM. We describe the development and inter-rater reliability of the CAT, and the frequency of lesions endorsed in a large population of juvenile IIM patients. Methods. The CAT includes 10 activity, 4 damage and 7 combined lesions. Thirty-two photographic slides depicting IIM skin lesions were assessed by 11 raters. One hundred and twenty-three children were assessed by 11 paediatric rheumatologists at 10 centres. Inter-rater reliability was assessed using simple agreements and intra-class correlation coefficients (ICC). Results. Simple agreements in recognizing lesions as present or absent were generally high (0.5-1.0). ICCs for CAT lesions were moderate (0.4-0.75) in both slides and real patients. ICCs for the CAT activity and damage scores were 0.71 and 0.81, respectively. CAT activity scores ranged from 0 to 44 (median 7, potential range 0-96) and CAT damage scores ranged from 0 to 13 (median 1, potential range 0-22). The most common cutaneous lesions endorsed were periungual capillary loop changes (63{\%}), Gottron's papules/sign (53{\%}), heliotrope rash (49{\%}) and malar/ facial erythema (49{\%}). Conclusions. Total CAT activity and damage scores have moderate to good reliability. Assessors generally agree on the presence of a variety of cutaneous lesions. The CAT is a promising, semi-quantitative tool to comprehensively assess skin disease activity and damage in IIM.",
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T2 - Development and reliability in juvenile idiopathic inflammatory myopathy

AU - Huber, Adam M.

AU - Dugan, E. M.

AU - Lachenbruch, P. A.

AU - Feldman, B. M.

AU - Perez, M. D.

AU - Zemel, L. S.

AU - Lindsley, C. B.

AU - Rennebohm, R. M.

AU - Wallace, C. A.

AU - Passo, M. H.

AU - Reed, A. M.

AU - Bowyer, S. L.

AU - Ballinger, S. H.

AU - Miller, F. W.

AU - Rider, L. G.

AU - Colbert, Robert

AU - DeInocencio, Jaime

AU - Griffin, Thomas

AU - Hashkes, Philip

AU - Hirsch, Raphael

AU - Kredich, Deborah

AU - Laxer, Ronald

AU - Levinson, Joseph

AU - Lovell, Daniel

AU - Ruperto, Nicola

AU - Silverman, Earl

AU - Sundel, Robert

AU - Vogelgesang, Scott

PY - 2007/10

Y1 - 2007/10

N2 - Objectives. Clinical care and therapeutic trials in idiopathic inflammatory myopathies (IIM) require accurate and consistent assessment of cutaneous involvement. The Cutaneous Assessment Tool (CAT) was designed to measure skin activity and damage in IIM. We describe the development and inter-rater reliability of the CAT, and the frequency of lesions endorsed in a large population of juvenile IIM patients. Methods. The CAT includes 10 activity, 4 damage and 7 combined lesions. Thirty-two photographic slides depicting IIM skin lesions were assessed by 11 raters. One hundred and twenty-three children were assessed by 11 paediatric rheumatologists at 10 centres. Inter-rater reliability was assessed using simple agreements and intra-class correlation coefficients (ICC). Results. Simple agreements in recognizing lesions as present or absent were generally high (0.5-1.0). ICCs for CAT lesions were moderate (0.4-0.75) in both slides and real patients. ICCs for the CAT activity and damage scores were 0.71 and 0.81, respectively. CAT activity scores ranged from 0 to 44 (median 7, potential range 0-96) and CAT damage scores ranged from 0 to 13 (median 1, potential range 0-22). The most common cutaneous lesions endorsed were periungual capillary loop changes (63%), Gottron's papules/sign (53%), heliotrope rash (49%) and malar/ facial erythema (49%). Conclusions. Total CAT activity and damage scores have moderate to good reliability. Assessors generally agree on the presence of a variety of cutaneous lesions. The CAT is a promising, semi-quantitative tool to comprehensively assess skin disease activity and damage in IIM.

AB - Objectives. Clinical care and therapeutic trials in idiopathic inflammatory myopathies (IIM) require accurate and consistent assessment of cutaneous involvement. The Cutaneous Assessment Tool (CAT) was designed to measure skin activity and damage in IIM. We describe the development and inter-rater reliability of the CAT, and the frequency of lesions endorsed in a large population of juvenile IIM patients. Methods. The CAT includes 10 activity, 4 damage and 7 combined lesions. Thirty-two photographic slides depicting IIM skin lesions were assessed by 11 raters. One hundred and twenty-three children were assessed by 11 paediatric rheumatologists at 10 centres. Inter-rater reliability was assessed using simple agreements and intra-class correlation coefficients (ICC). Results. Simple agreements in recognizing lesions as present or absent were generally high (0.5-1.0). ICCs for CAT lesions were moderate (0.4-0.75) in both slides and real patients. ICCs for the CAT activity and damage scores were 0.71 and 0.81, respectively. CAT activity scores ranged from 0 to 44 (median 7, potential range 0-96) and CAT damage scores ranged from 0 to 13 (median 1, potential range 0-22). The most common cutaneous lesions endorsed were periungual capillary loop changes (63%), Gottron's papules/sign (53%), heliotrope rash (49%) and malar/ facial erythema (49%). Conclusions. Total CAT activity and damage scores have moderate to good reliability. Assessors generally agree on the presence of a variety of cutaneous lesions. The CAT is a promising, semi-quantitative tool to comprehensively assess skin disease activity and damage in IIM.

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