The cystic fibrosis gene is not likely to be involved in chronic obstructive pulmonary disease.

P. Gasparini, A. Savoia, M. Luisetti, V. Peona, P. F. Pignatti

Research output: Contribution to journalArticle

Abstract

The etiology of chronic obstructive pulmonary disease (COPD) is still unknown, and both genetic and environmental factors may play a role. Some clinical aspects of COPD occur similarly in cystic fibrosis (CF), particularly in adult patients. A DNA polymorphic marker in strong linkage disequilibrium with the CF locus has been used to check the hypothesis that mutations of this locus might be involved in COPD. Its allele frequencies have been found to be in equilibrium in COPD patients as well as in appropriate control subjects. The determinants possibly involved in genetic predisposition to COPD therefore do not seem to comprise CF gene mutations.

Original languageEnglish
Pages (from-to)297-299
Number of pages3
JournalAmerican Journal of Respiratory Cell and Molecular Biology
Volume2
Issue number3
Publication statusPublished - Mar 1990

ASJC Scopus subject areas

  • Cell Biology

Fingerprint Dive into the research topics of 'The cystic fibrosis gene is not likely to be involved in chronic obstructive pulmonary disease.'. Together they form a unique fingerprint.

  • Cite this