The cytoskeletal arrangements necessary to neurogenesis

Claudia Compagnucci, Fiorella Piemonte, Antonella Sferra, Emanuela Piermarini, Enrico Bertini

Research output: Contribution to journalArticlepeer-review

Abstract

During the process of neurogenesis, the stem cell committed to the neuronal cell fate starts a series of molecular and morphological changes. The understanding of the physio-pathology of mechanisms controlling the molecular and morphological changes occurring during neuronal differentiation is fundamental to the development of effective therapies for many neurologic diseases. Unfortunately, our knowledge of the biological events occurring in the cell during neuronal differentiation is still poor. In this study, we focus preliminarily on the relevance of the cytoskeletal rearrangements, which earlier drive the morphology of the neuronal precursors, and later the migrating/mature neurons. In fact, neuritogenesis, neurite branching, outgrowth and retraction are seminal to the development of a fully functional nervous system. With this in mind, we highlight the importance of iPSC technology to study the processes of cytoskeletal-driven morphological changes during neuronal differentiation.

Original languageEnglish
Pages (from-to)19414-19429
Number of pages16
JournalOncotarget
Volume7
Issue number15
DOIs
Publication statusPublished - Apr 12 2016

Keywords

  • Actin
  • Cytoskeleton
  • Induced pluripotent stem cells (iPSCs)
  • Neuritogenesis
  • Neurogenesis
  • Tubulins

ASJC Scopus subject areas

  • Oncology

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