Abstract
During the process of neurogenesis, the stem cell committed to the neuronal cell fate starts a series of molecular and morphological changes. The understanding of the physio-pathology of mechanisms controlling the molecular and morphological changes occurring during neuronal differentiation is fundamental to the development of effective therapies for many neurologic diseases. Unfortunately, our knowledge of the biological events occurring in the cell during neuronal differentiation is still poor. In this study, we focus preliminarily on the relevance of the cytoskeletal rearrangements, which earlier drive the morphology of the neuronal precursors, and later the migrating/mature neurons. In fact, neuritogenesis, neurite branching, outgrowth and retraction are seminal to the development of a fully functional nervous system. With this in mind, we highlight the importance of iPSC technology to study the processes of cytoskeletal-driven morphological changes during neuronal differentiation.
| Original language | English |
|---|---|
| Pages (from-to) | 19414-19429 |
| Number of pages | 16 |
| Journal | Oncotarget |
| Volume | 7 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - Apr 12 2016 |
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Keywords
- Actin
- Cytoskeleton
- Induced pluripotent stem cells (iPSCs)
- Neuritogenesis
- Neurogenesis
- Tubulins
ASJC Scopus subject areas
- Oncology
Cite this
The cytoskeletal arrangements necessary to neurogenesis. / Compagnucci, Claudia; Piemonte, Fiorella; Sferra, Antonella; Piermarini, Emanuela; Bertini, Enrico.
In: Oncotarget, Vol. 7, No. 15, 12.04.2016, p. 19414-19429.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The cytoskeletal arrangements necessary to neurogenesis
AU - Compagnucci, Claudia
AU - Piemonte, Fiorella
AU - Sferra, Antonella
AU - Piermarini, Emanuela
AU - Bertini, Enrico
PY - 2016/4/12
Y1 - 2016/4/12
N2 - During the process of neurogenesis, the stem cell committed to the neuronal cell fate starts a series of molecular and morphological changes. The understanding of the physio-pathology of mechanisms controlling the molecular and morphological changes occurring during neuronal differentiation is fundamental to the development of effective therapies for many neurologic diseases. Unfortunately, our knowledge of the biological events occurring in the cell during neuronal differentiation is still poor. In this study, we focus preliminarily on the relevance of the cytoskeletal rearrangements, which earlier drive the morphology of the neuronal precursors, and later the migrating/mature neurons. In fact, neuritogenesis, neurite branching, outgrowth and retraction are seminal to the development of a fully functional nervous system. With this in mind, we highlight the importance of iPSC technology to study the processes of cytoskeletal-driven morphological changes during neuronal differentiation.
AB - During the process of neurogenesis, the stem cell committed to the neuronal cell fate starts a series of molecular and morphological changes. The understanding of the physio-pathology of mechanisms controlling the molecular and morphological changes occurring during neuronal differentiation is fundamental to the development of effective therapies for many neurologic diseases. Unfortunately, our knowledge of the biological events occurring in the cell during neuronal differentiation is still poor. In this study, we focus preliminarily on the relevance of the cytoskeletal rearrangements, which earlier drive the morphology of the neuronal precursors, and later the migrating/mature neurons. In fact, neuritogenesis, neurite branching, outgrowth and retraction are seminal to the development of a fully functional nervous system. With this in mind, we highlight the importance of iPSC technology to study the processes of cytoskeletal-driven morphological changes during neuronal differentiation.
KW - Actin
KW - Cytoskeleton
KW - Induced pluripotent stem cells (iPSCs)
KW - Neuritogenesis
KW - Neurogenesis
KW - Tubulins
UR - http://www.scopus.com/inward/record.url?scp=84964715469&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84964715469&partnerID=8YFLogxK
U2 - 10.18632/oncotarget.6838
DO - 10.18632/oncotarget.6838
M3 - Article
AN - SCOPUS:84964715469
VL - 7
SP - 19414
EP - 19429
JO - Oncotarget
JF - Oncotarget
SN - 1949-2553
IS - 15
ER -