Chirurgia cardiaca, bypass cardiopolmonare e risposta infiammatoria dell'organismo. Parte I: Alterazioni a carico dei processi emostatici e del complemento

Translated title of the contribution: The damaging effects of cardiopulmonary bypass. Part I: Alterations in hemostasis and complement

Alessandro Parolari, Francesco Alamanni, Carlo Antona, Monica Stanghellini, Stefania Sandano, Rita Spirito, Alberto Repossini, Andrea Sala, Paolo Biglioli

Research output: Contribution to journalArticlepeer-review

Abstract

The use of cardiopulmonary bypass for surgical cardiac procedures is characterized by a whole-body inflammatory reaction due to the contact of blood through nonendothelialized surfaces; this stimulates the organism to recognize the cardiopulmonary bypass system as "nonself" and to activate specific (immune) and nonspecific (inflammatory) responses. These responses are then related with postoperative damage to many body systems, like pulmonary, renal or brain dysfunction, excessive bleeding and postoperative sepsis. In this paper, present knowledge on untoward responses of the patient to the use of cardiopulmonary bypass in cardiac surgery is reviewed and discussed, particularly focusing on the perturbation of the hemostasis and of the complement activation system.

Translated title of the contributionThe damaging effects of cardiopulmonary bypass. Part I: Alterations in hemostasis and complement
Original languageItalian
Pages (from-to)431-446
Number of pages16
JournalGiornale Italiano di Cardiologia
Volume26
Issue number4
Publication statusPublished - Apr 1996

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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