Abstract
The use of cardiopulmonary bypass for surgical cardiac procedures is characterized by a whole-body inflammatory reaction due to the contact of blood through nonendothelialized surfaces; this stimulates the organism to recognize the cardiopulmonary bypass system as "nonself" and to activate specific (immune) and nonspecific (inflammatory) responses. These responses are then related with postoperative damage to many body systems of the body, like pulmonary, renal or brain dysfunction, excessive bleeding and postoperative sepsis. In this paper, present knowledge on untoward responses of the patient to cardiopulmonary bypass in cardiac surgery is reviewed and discussed, particularly focusing on the perturbation of the leukocytes, of the hormones and of the products of the arachidonic acid cascade.
| Original language | Italian |
|---|---|
| Pages (from-to) | 545-561 |
| Number of pages | 17 |
| Journal | Giornale Italiano di Cardiologia |
| Volume | 26 |
| Issue number | 8 |
| Publication status | Published - 1996 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
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Chirurgia cardiaca, bypass cardiopolmonare e risposta infiammatoria dell'organismo, parte II : alterazioni dei leucociti, dei derivati dell'acido arachidonico e degli ormoni. / Parolari, Alessandro; Alamanni, Francesco; Antona, Carlo; Stanghellini, Monica; Rossi, Fabiana; Gerometta, Piersilvio; Cavoretto, Dario; Arena, D. C Vincenzo; Biglioli, Paolo.
In: Giornale Italiano di Cardiologia, Vol. 26, No. 8, 1996, p. 545-561.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chirurgia cardiaca, bypass cardiopolmonare e risposta infiammatoria dell'organismo, parte II
T2 - alterazioni dei leucociti, dei derivati dell'acido arachidonico e degli ormoni
AU - Parolari, Alessandro
AU - Alamanni, Francesco
AU - Antona, Carlo
AU - Stanghellini, Monica
AU - Rossi, Fabiana
AU - Gerometta, Piersilvio
AU - Cavoretto, Dario
AU - Arena, D. C Vincenzo
AU - Biglioli, Paolo
PY - 1996
Y1 - 1996
N2 - The use of cardiopulmonary bypass for surgical cardiac procedures is characterized by a whole-body inflammatory reaction due to the contact of blood through nonendothelialized surfaces; this stimulates the organism to recognize the cardiopulmonary bypass system as "nonself" and to activate specific (immune) and nonspecific (inflammatory) responses. These responses are then related with postoperative damage to many body systems of the body, like pulmonary, renal or brain dysfunction, excessive bleeding and postoperative sepsis. In this paper, present knowledge on untoward responses of the patient to cardiopulmonary bypass in cardiac surgery is reviewed and discussed, particularly focusing on the perturbation of the leukocytes, of the hormones and of the products of the arachidonic acid cascade.
AB - The use of cardiopulmonary bypass for surgical cardiac procedures is characterized by a whole-body inflammatory reaction due to the contact of blood through nonendothelialized surfaces; this stimulates the organism to recognize the cardiopulmonary bypass system as "nonself" and to activate specific (immune) and nonspecific (inflammatory) responses. These responses are then related with postoperative damage to many body systems of the body, like pulmonary, renal or brain dysfunction, excessive bleeding and postoperative sepsis. In this paper, present knowledge on untoward responses of the patient to cardiopulmonary bypass in cardiac surgery is reviewed and discussed, particularly focusing on the perturbation of the leukocytes, of the hormones and of the products of the arachidonic acid cascade.
KW - Cardiac surgery
KW - Cardiopulmonary bypass
UR - http://www.scopus.com/inward/record.url?scp=0030144070&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030144070&partnerID=8YFLogxK
M3 - Articolo
VL - 26
SP - 545
EP - 561
JO - Giornale Italiano di Cardiologia
JF - Giornale Italiano di Cardiologia
SN - 0046-5968
IS - 8
ER -