Chirurgia cardiaca, bypass cardiopolmonare e risposta infiammatoria dell'organismo, parte II: alterazioni dei leucociti, dei derivati dell'acido arachidonico e degli ormoni

Translated title of the contribution: The damaging effects of cardiopulmonary bypass. Part II: Alterations in leukocytes, prostaglandins and hormones

Alessandro Parolari, Francesco Alamanni, Carlo Antona, Monica Stanghellini, Fabiana Rossi, Piersilvio Gerometta, Dario Cavoretto, D. C Vincenzo Arena, Paolo Biglioli

Research output: Contribution to journalArticle

Abstract

The use of cardiopulmonary bypass for surgical cardiac procedures is characterized by a whole-body inflammatory reaction due to the contact of blood through nonendothelialized surfaces; this stimulates the organism to recognize the cardiopulmonary bypass system as "nonself" and to activate specific (immune) and nonspecific (inflammatory) responses. These responses are then related with postoperative damage to many body systems of the body, like pulmonary, renal or brain dysfunction, excessive bleeding and postoperative sepsis. In this paper, present knowledge on untoward responses of the patient to cardiopulmonary bypass in cardiac surgery is reviewed and discussed, particularly focusing on the perturbation of the leukocytes, of the hormones and of the products of the arachidonic acid cascade.

Original languageItalian
Pages (from-to)545-561
Number of pages17
JournalGiornale Italiano di Cardiologia
Volume26
Issue number8
Publication statusPublished - 1996

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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