The dark side of the moon: The PI3K/PTEN/AKT pathway in colorectal carcinoma

Nicola Silvestris; Stefania Tommasi; Daniela Petriella; Daniele Santini; Ettore Fistola; Antonio Russo; Gianmauro Numico; Giuseppe Tonini; Evaristo Maiello; Giuseppe Colucci

doi:10.1159/000258498

The dark side of the moon: The PI3K/PTEN/AKT pathway in colorectal carcinoma

Nicola Silvestris, Stefania Tommasi, Daniela Petriella, Daniele Santini, Ettore Fistola, Antonio Russo, Gianmauro Numico, Giuseppe Tonini, Evaristo Maiello, Giuseppe Colucci

Research output: Contribution to journal › Article › peer-review

Abstract

Wild-type KRAS status is required but not sufficient to confer sensitivity to anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (mAbs) in colorectal cancer patients. As a consequence, one of the major challenges is to identify, in non-mutant KRAS patients, other markers that can predict lack of response to this therapy. Small series have investigated the clinical effect of PIK3CA mutations on resistance to anti-EGFR mAbs and discrepant results have been observed. Furthermore, PTEN loss in metastases may be predictive of resistance to anti-EGFR mAbs, even if PTEN determination is far from an immediate clinical application. The introduction of modulators of the PI3K/AKT/mTOR pathway as potential targeted anticancer drugs is encouraging, but this attractive therapy option is still at an early stage of development.

Original language	English
Pages (from-to)	69-74
Number of pages	6
Journal	Oncology
Volume	77
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1159/000258498
Publication status	Published - Feb 2010

Keywords

AKT
Cetuximab
MTOR
Panitumumab
Phosphoinositide 3-kinases
PTEN

ASJC Scopus subject areas

Cancer Research
Oncology

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The dark side of the moon : The PI3K/PTEN/AKT pathway in colorectal carcinoma. / Silvestris, Nicola ; Tommasi, Stefania; Petriella, Daniela; Santini, Daniele; Fistola, Ettore; Russo, Antonio; Numico, Gianmauro; Tonini, Giuseppe; Maiello, Evaristo; Colucci, Giuseppe.

In: Oncology, Vol. 77, No. SUPPL. 1, 02.2010, p. 69-74.

Research output: Contribution to journal › Article › peer-review

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abstract = "Wild-type KRAS status is required but not sufficient to confer sensitivity to anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (mAbs) in colorectal cancer patients. As a consequence, one of the major challenges is to identify, in non-mutant KRAS patients, other markers that can predict lack of response to this therapy. Small series have investigated the clinical effect of PIK3CA mutations on resistance to anti-EGFR mAbs and discrepant results have been observed. Furthermore, PTEN loss in metastases may be predictive of resistance to anti-EGFR mAbs, even if PTEN determination is far from an immediate clinical application. The introduction of modulators of the PI3K/AKT/mTOR pathway as potential targeted anticancer drugs is encouraging, but this attractive therapy option is still at an early stage of development.",

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AU - Fistola, Ettore

AU - Russo, Antonio

AU - Numico, Gianmauro

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The dark side of the moon: The PI3K/PTEN/AKT pathway in colorectal carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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