TY - JOUR
T1 - The dark that matters
T2 - Long noncoding RNAs as master regulators of cellular metabolism in noncommunicable diseases
AU - Mongelli, Alessia
AU - Martelli, Fabio
AU - Farsetti, Antonella
AU - Gaetano, Carlo
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Non-coding RNAs are pivotal for many cellular functions, such as splicing, gene regulation, chromosome structure, and hormone-like activity. Here, we will report about the biology and the general molecular mechanisms associated with long non-coding RNAs (lncRNAs), a class of >200 nucleotides-long ribonucleic acid sequences, and their role in chronic non-transmissible diseases. In particular, we will summarize knowledge about some of the best-characterized lncRNAs, such as H19 and MALAT1, and how they regulate carbohydrate and lipid metabolism as well as protein synthesis and degradation. Evidence is discussed about how lncRNAs expression might affect cellular and organismal metabolism and whether their modulation could provide ground for the development of innovative treatments.
AB - Non-coding RNAs are pivotal for many cellular functions, such as splicing, gene regulation, chromosome structure, and hormone-like activity. Here, we will report about the biology and the general molecular mechanisms associated with long non-coding RNAs (lncRNAs), a class of >200 nucleotides-long ribonucleic acid sequences, and their role in chronic non-transmissible diseases. In particular, we will summarize knowledge about some of the best-characterized lncRNAs, such as H19 and MALAT1, and how they regulate carbohydrate and lipid metabolism as well as protein synthesis and degradation. Evidence is discussed about how lncRNAs expression might affect cellular and organismal metabolism and whether their modulation could provide ground for the development of innovative treatments.
KW - Amino acids
KW - Cancer
KW - Carbohydrates
KW - Cardiovascular
KW - Diabetes
KW - Lipids
KW - LncRNA
KW - Metabolism
UR - http://www.scopus.com/inward/record.url?scp=85068260285&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85068260285&partnerID=8YFLogxK
U2 - 10.3389/fphys.2019.00369
DO - 10.3389/fphys.2019.00369
M3 - Review article
AN - SCOPUS:85068260285
VL - 10
JO - Frontiers in Physiology
JF - Frontiers in Physiology
SN - 1664-042X
IS - MAY
M1 - 369
ER -