The dark that matters: Long noncoding RNAs as master regulators of cellular metabolism in noncommunicable diseases

Research output: Contribution to journalReview articlepeer-review

Abstract

Non-coding RNAs are pivotal for many cellular functions, such as splicing, gene regulation, chromosome structure, and hormone-like activity. Here, we will report about the biology and the general molecular mechanisms associated with long non-coding RNAs (lncRNAs), a class of >200 nucleotides-long ribonucleic acid sequences, and their role in chronic non-transmissible diseases. In particular, we will summarize knowledge about some of the best-characterized lncRNAs, such as H19 and MALAT1, and how they regulate carbohydrate and lipid metabolism as well as protein synthesis and degradation. Evidence is discussed about how lncRNAs expression might affect cellular and organismal metabolism and whether their modulation could provide ground for the development of innovative treatments.

Original languageEnglish
Article number369
JournalFrontiers in Physiology
Volume10
Issue numberMAY
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • Amino acids
  • Cancer
  • Carbohydrates
  • Cardiovascular
  • Diabetes
  • Lipids
  • LncRNA
  • Metabolism

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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