TY - JOUR
T1 - The Default Mode Network Connectivity Predicts Cognitive Recovery in Severe Acquired Brain Injured Patients
T2 - A Longitudinal Study
AU - Falletta Caravasso, Chiara
AU - De Pasquale, Francesco
AU - Ciurli, Paola
AU - Catani, Sheila
AU - Formisano, Rita
AU - Sabatini, Umberto
PY - 2016/7/1
Y1 - 2016/7/1
N2 - To study the functional connectivity in patients with severe acquired brain injury is very challenging for their high level of disability because of a prolonged period of coma, extended lesions, and several cognitive and behavioral disorders. In this article, we investigated in these patients the default mode network and somatomotor connectivity changes at rest longitudinally, in the subacute and late phase after brain injury. The aim of the study is to characterize such connectivity patterns and relate the observed changes to clinical and neuropsychological outcomes of these patients after a period of intensive neurorehabilitation. Our findings show within the default mode network a disruption of connectivity of medial pre-frontal regions and a significant change of amplitude of internal connections. Notably, strongest changes in functional connectivity significantly correlated to consistent clinical and cognitive recovery. This evidence seems to indicate that the reorganization of the Default Mode Network may represent a valid biomarker for the cognitive recovery in patients with severe acquired brain injury.
AB - To study the functional connectivity in patients with severe acquired brain injury is very challenging for their high level of disability because of a prolonged period of coma, extended lesions, and several cognitive and behavioral disorders. In this article, we investigated in these patients the default mode network and somatomotor connectivity changes at rest longitudinally, in the subacute and late phase after brain injury. The aim of the study is to characterize such connectivity patterns and relate the observed changes to clinical and neuropsychological outcomes of these patients after a period of intensive neurorehabilitation. Our findings show within the default mode network a disruption of connectivity of medial pre-frontal regions and a significant change of amplitude of internal connections. Notably, strongest changes in functional connectivity significantly correlated to consistent clinical and cognitive recovery. This evidence seems to indicate that the reorganization of the Default Mode Network may represent a valid biomarker for the cognitive recovery in patients with severe acquired brain injury.
KW - cognitive recovery
KW - functional connectivity
KW - magnetic resonance imaging
KW - neurorehabilitation
KW - severe acquired brain injury
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U2 - 10.1089/neu.2015.4003
DO - 10.1089/neu.2015.4003
M3 - Article
AN - SCOPUS:84975720703
VL - 33
SP - 1247
EP - 1262
JO - Journal of Neurotrauma
JF - Journal of Neurotrauma
SN - 0897-7151
IS - 13
ER -