The definition of non-responder to multiple sclerosis treatment

Neuroimaging markers

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

MRI is the main paraclinical tool used both to diagnose multiple sclerosis (MS) and to evaluate the efficacy of experimental treatments in phase II and III clinical trials. In the latter context, a major issue is represented by the weak correlations found between clinical and MRI aspects in the case of established MS, which are particularly evident when individual patients are considered. As a consequence, the definition of response to MS treatment, when based upon MRI aspects, remains a challenging task. Although the use of MRI-derived quantities to define treatment options and strategies at an individual patient level is supported by recent evidence, only the integration of clinical and MRI data can be considered a reliable approach for the work-up of patients undergoing disease-modifying treatments.

Original languageEnglish
JournalNeurological Sciences
Volume29
Issue numberSUPPL. 2
DOIs
Publication statusPublished - Sep 2008

Fingerprint

Neuroimaging
Multiple Sclerosis
Phase III Clinical Trials
Phase II Clinical Trials
Therapeutics

Keywords

  • MRI
  • Multiple sclerosis
  • Treatment response

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

The definition of non-responder to multiple sclerosis treatment : Neuroimaging markers. / Rovaris, Marco.

In: Neurological Sciences, Vol. 29, No. SUPPL. 2, 09.2008.

Research output: Contribution to journalArticle

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