Abstract
Background & Aims: Screening for oesophageal varices (OV) using conventional oesophagogastroduodenoscopy (C-OGD) is invasive and requires costly monitoring, recovery, and decontamination facilities. We aimed to evaluate the technical feasibility, acceptability and accuracy of a novel, portable and disposable office-based transnasal endoscope (EG Scan™) compared to C-OGD as the reference standard. Methods: This was a prospective cohort study. Consecutive adult patients with cirrhosis were invited to participate. All subjects underwent the two procedures on the same day performed by two endoscopists in a blinded design. Patients completed preference and validated tolerability (10-point visual analogue scale (VAS)) questionnaires on day 0 and day 14 post procedures. Results: Forty-five of 50 patients (90%) completed both interventions. Mean age was 59 years and OV prevalence was 49%. Patients reported higher preference (percentage) and better experience (mean VAS) with EG Scan compared to C-OGD on day 0 (76.5% vs. 23.5%, P <0.001; 7.8 vs. 6.8, P = 0.058, respectively) and day 14 (77.8% vs. 22.2%, P <0.001; 7.0 vs. 5.5, P = 0.0013 respectively). Sensitivity and specificity of the EG Scan for the diagnosis of any size OV were 0.82 (95% confidence interval (CI) 0.60-0.95), and 0.78 (95% CI 0.56-0.93) respectively. Corresponding values for the diagnosis of clinically significant (medium/large) OV were 0.92 (95% CI 0.62-1.0), 0.97 (95% CI 0.84-1.0) respectively. No serious adverse events occurred. Conclusions: EG Scan accuracy was higher for the diagnosis of medium/large OV compared to any size OV. Patients' preference and overall experience of the EG Scan was favourable compared to C-OGD 14 days after procedures.
| Original language | English |
|---|---|
| Pages (from-to) | 1639-1648 |
| Number of pages | 10 |
| Journal | Liver International |
| Volume | 36 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2016 |
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Keywords
- Endoscopy
- Screening
- Transnasal
- Varices
ASJC Scopus subject areas
- Hepatology
Cite this
The detection of oesophageal varices using a novel, disposable, probe-based transnasal endoscope : A prospective diagnostic pilot study. / Sami, Sarmed S.; Ragunath, Krish; Wilkes, Emilie A.; James, Martin; Mansilla-Vivar, Rodrigo; Ortiz-Fernández-Sordo, Jacobo; White, Jonathan; Khanna, Amardeep; Coletta, Marina; Samuel, Sunil; Aithal, Guruprasad P.; Guha, Indra Neil.
In: Liver International, Vol. 36, No. 11, 2016, p. 1639-1648.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The detection of oesophageal varices using a novel, disposable, probe-based transnasal endoscope
T2 - A prospective diagnostic pilot study
AU - Sami, Sarmed S.
AU - Ragunath, Krish
AU - Wilkes, Emilie A.
AU - James, Martin
AU - Mansilla-Vivar, Rodrigo
AU - Ortiz-Fernández-Sordo, Jacobo
AU - White, Jonathan
AU - Khanna, Amardeep
AU - Coletta, Marina
AU - Samuel, Sunil
AU - Aithal, Guruprasad P.
AU - Guha, Indra Neil
PY - 2016
Y1 - 2016
N2 - Background & Aims: Screening for oesophageal varices (OV) using conventional oesophagogastroduodenoscopy (C-OGD) is invasive and requires costly monitoring, recovery, and decontamination facilities. We aimed to evaluate the technical feasibility, acceptability and accuracy of a novel, portable and disposable office-based transnasal endoscope (EG Scan™) compared to C-OGD as the reference standard. Methods: This was a prospective cohort study. Consecutive adult patients with cirrhosis were invited to participate. All subjects underwent the two procedures on the same day performed by two endoscopists in a blinded design. Patients completed preference and validated tolerability (10-point visual analogue scale (VAS)) questionnaires on day 0 and day 14 post procedures. Results: Forty-five of 50 patients (90%) completed both interventions. Mean age was 59 years and OV prevalence was 49%. Patients reported higher preference (percentage) and better experience (mean VAS) with EG Scan compared to C-OGD on day 0 (76.5% vs. 23.5%, P <0.001; 7.8 vs. 6.8, P = 0.058, respectively) and day 14 (77.8% vs. 22.2%, P <0.001; 7.0 vs. 5.5, P = 0.0013 respectively). Sensitivity and specificity of the EG Scan for the diagnosis of any size OV were 0.82 (95% confidence interval (CI) 0.60-0.95), and 0.78 (95% CI 0.56-0.93) respectively. Corresponding values for the diagnosis of clinically significant (medium/large) OV were 0.92 (95% CI 0.62-1.0), 0.97 (95% CI 0.84-1.0) respectively. No serious adverse events occurred. Conclusions: EG Scan accuracy was higher for the diagnosis of medium/large OV compared to any size OV. Patients' preference and overall experience of the EG Scan was favourable compared to C-OGD 14 days after procedures.
AB - Background & Aims: Screening for oesophageal varices (OV) using conventional oesophagogastroduodenoscopy (C-OGD) is invasive and requires costly monitoring, recovery, and decontamination facilities. We aimed to evaluate the technical feasibility, acceptability and accuracy of a novel, portable and disposable office-based transnasal endoscope (EG Scan™) compared to C-OGD as the reference standard. Methods: This was a prospective cohort study. Consecutive adult patients with cirrhosis were invited to participate. All subjects underwent the two procedures on the same day performed by two endoscopists in a blinded design. Patients completed preference and validated tolerability (10-point visual analogue scale (VAS)) questionnaires on day 0 and day 14 post procedures. Results: Forty-five of 50 patients (90%) completed both interventions. Mean age was 59 years and OV prevalence was 49%. Patients reported higher preference (percentage) and better experience (mean VAS) with EG Scan compared to C-OGD on day 0 (76.5% vs. 23.5%, P <0.001; 7.8 vs. 6.8, P = 0.058, respectively) and day 14 (77.8% vs. 22.2%, P <0.001; 7.0 vs. 5.5, P = 0.0013 respectively). Sensitivity and specificity of the EG Scan for the diagnosis of any size OV were 0.82 (95% confidence interval (CI) 0.60-0.95), and 0.78 (95% CI 0.56-0.93) respectively. Corresponding values for the diagnosis of clinically significant (medium/large) OV were 0.92 (95% CI 0.62-1.0), 0.97 (95% CI 0.84-1.0) respectively. No serious adverse events occurred. Conclusions: EG Scan accuracy was higher for the diagnosis of medium/large OV compared to any size OV. Patients' preference and overall experience of the EG Scan was favourable compared to C-OGD 14 days after procedures.
KW - Endoscopy
KW - Screening
KW - Transnasal
KW - Varices
UR - http://www.scopus.com/inward/record.url?scp=84971265411&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84971265411&partnerID=8YFLogxK
U2 - 10.1111/liv.13152
DO - 10.1111/liv.13152
M3 - Article
AN - SCOPUS:84971265411
VL - 36
SP - 1639
EP - 1648
JO - Liver International
JF - Liver International
SN - 1478-3223
IS - 11
ER -