The development of Ca2+ indicators: A breakthrough in pharmacological research

Jacopo Meldolesi

Research output: Contribution to journalArticlepeer-review


The development, beginning in 1979, of fluorescent Ca2+- specific indicators as research tools has revolutionized transmembrane signaling studies. In this article, the state of the art in the 'pre-Ca 2+-indicator' era and the rationale for the development of indicators trapped in the cytosol to investigate the cytosolic concentration of Ca2+ in mammalian cells are summarized. Subsequent extension of these studies to the level of the single cell, together with the unique impact that Ca2+ indicators have had on signaling research and the introduction of specific, fluorescent gene constructs that provide direct, high-resolution information about the intracellular concentration of Ca 2+, are also discussed.

Original languageEnglish
Pages (from-to)172-174
Number of pages3
JournalTrends in Pharmacological Sciences
Issue number4
Publication statusPublished - Apr 2004

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology


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