The development of human mast cells. An historical reappraisal

Domenico Ribatti

Research output: Contribution to journalArticlepeer-review


The understanding of mast cell (MC) differentiation is derived mainly from in vitro studies of different stages of stem and progenitor cells. The hematopoietic lineage development of human MCs is unique compared to other myeloid-derived cells. Human MCs originate from CD34+/CD117+/CD13+multipotent hematopoietic progenitors, which undergo transendothelial recruitment into peripheral tissues, where they complete differentiation. Stem cell factor (SCF) is a major chemotactic factor for MCs and their progenitors. SCF also elicits cell-cell and cell-substratum adhesion, facilitates the proliferation, and sustains the survival, differentiation, and maturation, of MCs. Because MC maturation is influenced by local microenvironmental factors, different MC phenotypes can develop in different tissues and organs.

Original languageEnglish
Pages (from-to)210-215
Number of pages6
JournalExperimental Cell Research
Issue number2
Publication statusPublished - Mar 15 2016


  • Bone marrow
  • Development
  • History of medicine
  • Mast cells

ASJC Scopus subject areas

  • Cell Biology

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