The development of hyperventilation in patients with chronic heart failure and Cheyne-Stokes respiration: A possible role of chronic hypoxia

Francesco Fanfulla, Andrea Mortara, Roberto Maestri, Gian Domenico Pinna, Claudio Bruschi, Franco Cobelli, Ciro Rampulla

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To analyze the relationship between daytime respiratory and cardiac function in patients with compensated chronic heart failure (CHF) with and without periodic breathing (PB) or Cheyne-Stokes respiration (CSR). Patients: We studied 132 patients (female, 13%; mean age, 53±8 years; body mass index, 25.9±3.5 kg/m2; left ventricular ejection fraction 2 were similar in the three groups of patients considered. In contrast, patients with PB or CSR had an increased minute ventilation and reduced PaCO2 values. Interestingly, patients with PB or CSR had lower values of arterial content of O2. and systemic oxygen transport (SOT) than patients with a normal breathing pattern (SOT, 394±9.8, 347±9.6, 438±11 mL of O2/min/m2, respectively; analysis of variance p2 with PCWP (r=0.26; p2 was significantly correlated with SOT, LECT, and CI (r=0.51; r =0.26; p2=0.4; p

Original languageEnglish
Pages (from-to)1083-1090
Number of pages8
JournalChest
Volume114
Issue number4
Publication statusPublished - 1998

Keywords

  • Cheyne-Stokes respiration
  • Chronic heart failure
  • Oxygen
  • Pattern of breathing
  • Respiratory function

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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