The development of platinum compounds and their possible combination

Lara Maria Pasetto, Mario Rosario D'Andrea, Alba Ariela Brandes, Elena Rossi, Silvio Monfardini

Research output: Contribution to journalArticlepeer-review

Abstract

Cisplatin plays a central role in cancer chemotherapy in spite of its toxicity. To circumvent this toxicity and to enhance its therapeutic index a lot of preclinical and clinical studies have been conducted and several thousand analogues have been synthesized. Much more analysis remains to be done, but nowadays, the absence of any definitive, biologically interpretable molecular predictor of activity is consistent with the idea that platinum compounds have multiple intracellular targets and that cells can have multiple mechanisms of resistance. This review analyses a part of these platinum compounds analyzed to date, their mechanism of action, resistance and the future trends in this sector.

Original languageEnglish
Pages (from-to)59-75
Number of pages17
JournalCritical Reviews in Oncology/Hematology
Volume60
Issue number1
DOIs
Publication statusPublished - Oct 2006

Keywords

  • Combination
  • Platinum analogues
  • Review

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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