TY - JOUR
T1 - The development of the vascular system
T2 - A historical overview
AU - Ribatti, Domenico
AU - Nico, Beatrice
AU - Crivellato, Enrico
PY - 2015
Y1 - 2015
N2 - Development of the vascular system involves a complex sequence of inductive and differentiating signals leading to vasculogenesis and/or angiogenesis. Dissecting and exploring this process in its multifaceted morphological and molecular aspects has represented a basic contribution and a fascinating adventure in the history of biology. Vasculogenesis, that is de novo formation of vascular channels, initiates early during embryo development and prevails at the beginning of embryo patterning and organ formation. Angiogenesis, the process of shaping new vessels from preexisting blood vessels, mainly operates during postnatal life. In this historical introduction, we try to retrace the early steps of scientific speculation on vascular development and to recapitulate the principal paths leading to our present appreciation of blood vessel formation.
AB - Development of the vascular system involves a complex sequence of inductive and differentiating signals leading to vasculogenesis and/or angiogenesis. Dissecting and exploring this process in its multifaceted morphological and molecular aspects has represented a basic contribution and a fascinating adventure in the history of biology. Vasculogenesis, that is de novo formation of vascular channels, initiates early during embryo development and prevails at the beginning of embryo patterning and organ formation. Angiogenesis, the process of shaping new vessels from preexisting blood vessels, mainly operates during postnatal life. In this historical introduction, we try to retrace the early steps of scientific speculation on vascular development and to recapitulate the principal paths leading to our present appreciation of blood vessel formation.
KW - Angiogenesis
KW - Endothelium
KW - Vascular system
KW - Vasculogenesis
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U2 - 10.1007/978-1-4939-1462-3_1
DO - 10.1007/978-1-4939-1462-3_1
M3 - Article
VL - 1214
JO - Methods in Molecular Biology
JF - Methods in Molecular Biology
SN - 1064-3745
ER -