The diabetic CKD patient - A major cardiovascular challenge

Irene M. Van Der Meer, Piero Ruggenenti, Giuseppe Remuzzi

Research output: Contribution to journalArticlepeer-review


The diabetic patient with chronic kidney disease (CKD) is at very high risk of cardiovascular disease (CVD). Primary and secondary CVD prevention is of major importance and should be targeted at both traditional cardiovascular risk factors and risk factors specific for patients with CKD, such as albuminuria, anaemia and CKD - mineral and bone disorder. However, treatment goals have largely been derived from clinical trials including patients with no or only mild CKD and may not be generalisable to patients with advanced renal disease. Moreover, in patients on renal replacement therapy, the association between traditional CVD risk factors and the incidence of CVD may be reversed, and pharmaceutical interventions that are beneficial in the general population may be ineffective or even harmful in this high-risk population. Those involved in the delivery of care to patients with diabetes and CKD need to be aware of these issues and should adopt an individualised approach to treatment.

Original languageEnglish
Pages (from-to)34-46
Number of pages13
JournalJournal of Renal Care
Issue numberSUPPL. 1
Publication statusPublished - May 2010


  • Cardiovascular
  • Chronic kidney disease
  • Diabetic
  • Haemodialysis
  • Proteinuria

ASJC Scopus subject areas

  • Nephrology
  • Advanced and Specialised Nursing


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