The diagnosis and treatment of aplastic anemia: a review

Maurizio Miano, Carlo Dufour

Research output: Contribution to journalArticlepeer-review


Aplastic anemia is a rare disorder characterized by suppression of bone marrow function resulting in progressive pancytopenia. A trigger-related abnormal T cell response facilitated by some genetic predisposition has been postulated as the pathogenetic mechanism leading to the overproduction of bone marrow-inhibiting cytokines. Immuno-mediated pathogenesis is confirmed by the response to immunosuppressive treatment (IST) (cyclosporin A+ATG), which represents the first-choice therapy for patients 

Original languageEnglish
Pages (from-to)527-535
Number of pages9
JournalInternational Journal of Hematology
Issue number6
Publication statusPublished - Apr 3 2015


  • Aplastic anemia
  • Diagnosis
  • Stem cell transplantation
  • Treatment

ASJC Scopus subject areas

  • Hematology


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